MétaCan
Menu
Back to cohort
Record W1967477962 · doi:10.1371/journal.pmed.0030094

Enrolling Women into HIV Preventive Vaccine Trials: An Ethical Imperative but a Logistical Challenge

2006· article· en· W1967477962 on OpenAlexafffund
Edward J. Mills, Stephanie Nixon, Sonal Singh, Sonam Dolma, Anjali Nayyar, Sushma Kapoor

Bibliographic record

VenuePLoS Medicine · 2006
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsYork UniversityMcMaster University
FundersOntario HIV Treatment Network
KeywordsHIV vaccineHuman immunodeficiency virus (HIV)MedicineAIDS VaccinesPre-exposure prophylaxisClinical trialFamily medicineAlternative medicineVirologyEnvironmental healthVaccine trialMen who have sex with menInternal medicine

Abstract

fetched live from OpenAlex

Mills and colleagues argue that the challenge of enrolling women into HIV vaccine trials must be overcome in order for trials to be considered ethical, valid, and generalizable.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.026
metaresearch head score (Gemma)0.165
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.347
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0260.165
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.007
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.471
GPT teacher head0.574
Teacher spread0.103 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations61
Published2006
Admission routes2
Has abstractyes

Explore more

Same venuePLoS MedicineSame topicEthics in Clinical ResearchFrench-language works237,207