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Record W1977880538 · doi:10.1136/jmedgenet-2012-101141

Public funding for genomics: where does Canada stand?

2012· article· en· W1977880538 on OpenAlexaffabout
Constantin Polychronakos

Bibliographic record

VenueJournal of Medical Genetics · 2012
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsMcGill University Health Centre
Fundersnot available
KeywordsGenomicsBiologyComputational biologyGeneticsGenomeGene

Abstract

fetched live from OpenAlex

After more than six years of funding exclusive projects in forestry and agriculture, Genome Canada has now announced a $67.5 million funding competition for large-scale genomics projects in human health, with focus on personalised medicine.i The human genomics community of this country understandably rejoiced at this long overdue announcement that gives them, for the first time in years, the means to compete internationally (http://www.genomecanada.ca/en/portfolio/research/2012-competition.aspx). Canada has been fairly generous in funding human-health related research but mostly through the Canadian Institutes of Health Research (CIHR) or the Canada Foundation for Innovation, neither of which has within its mandate to fund the type of specific multimillion-dollar project that is usually thought of as genomics. The typical CIHR grant, for example, rarely exceeds $1 million (200 000 over 5 years) in direct costs. The elation over the announcement of this funding opportunity in late 2011 soon gave way to sober reflection when prospective applicants started looking at the fine print. The terms of reference made it clear that this is a call for proposals with a very strong utilitarian angle, ‘capable of concrete deliverables by the end of the funding period that will have clinical utility and/or practical applicability’ and ‘social and/or economic benefits … realised within a short time-frame after the end of the project’, to quote from the official announcement. The funding period is four years (only coincidentally, I am sure, the time to the next federal election). How short the additional ‘short time-frame’ might be, is left to interpretation but the context leaves little doubt that it cannot be more than a couple of years. How else can applicants ‘… demonstrate end-user engagement in the development and execution of the research plan’? Examples of end-users whose interest must be attracted sufficiently for them to participate in the ‘execution of the research’ and be …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.020
metaresearch head score (Gemma)0.055
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Incentives · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.980
Threshold uncertainty score0.973

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0200.055
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0040.009
Science and technology studies0.0230.014
Scholarly communication0.0370.019
Open science0.0050.010
Research integrity0.0190.019
Insufficient payload (model declined to judge)0.0410.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.529
GPT teacher head0.545
Teacher spread0.015 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainIncentives
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2012
Admission routes2
Has abstractyes

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