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Record W1983270011 · doi:10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

2012· review· en· W1983270011 on OpenAlexafffund
Patrick Sleiman, Jonathan P. Bradfield, Johan C. de Jongste, Vincent W. V. Jaddoe, H. Rob Taal, André G. Uitterlinden, Dennis O. Mook‐Kanamori, Cornelia M. van Duijn, John P. Kemp, David M. Evans, Beaté St Pourcain, George Davey Smith, Nicholas J. Timpson, André Scherag, Stephen Eyre, Philippe Froguel, Craig E. Pennell, Nicole M. Warrington, Diane J. Berry, Elina Hyppönen, Chris Power, Karani S. Vimaleswaran, Claus Holst, Thorkild I. A. Sørensen, Paul Elliott, Beatriz Valcárcel, Shikta Das, Joachim Heinrich, Elisabeth Thiering, Rany M. Salem, Aarno Palotie, W. James Gauderman, Frank D. Gilliland, Fredrick R. Schumacher, Mohamed Hassanein, Elisabeth Widén, Diana L. Cousminer, Jianhua Zhao, Struan F.A. Grant, Robert I. Berkowitz, Ivonne Jarick, Ralf J.P. van der Valk, Dirkje S. Postma, Dorret I. Boomsma, Reedik Mägi, Cecilia M. Lindgren, Colin Boreham, Charlotte E. Neville, Luís A. Moreno, Anneli Pouta, Anna‐Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, Johan G. Eriksson, Panos Deloukas, Eleanor Wheeler, Inês Barroso, Aline Meirhaeghe, Jean Dallongeville, Susan M. Ring, George McMahon, Jessica L. Buxton, Alexandra I. F. Blakemore, Mònica Guxens, Mariona Bustamante, Matthew W. Gillman, Eskil Kreiner‐Møller, Hans Bisgaard, I. Sadaf Farooqi, Lyle J. Palmer, Johannes Hebebrand, Anke Hinney, Marjo‐Riitta Järvelin

Bibliographic record

VenueNature Genetics · 2012
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsLunenfeld-Tanenbaum Research InstituteOntario Institute for Cancer ResearchMcMaster University
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Mental HealthNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteZonMwNational Institute of Environmental Health SciencesCanadian Institutes of Health ResearchU.S. Department of Veterans AffairsNational Institute for Health and Care ResearchBritish Heart FoundationWellcome Trust
KeywordsBiologyGenome-wide association studyChildhood obesityMeta-analysisGeneticsGenetic associationObesityComputational biologyAssociation (psychology)Evolutionary biologySingle-nucleotide polymorphismGeneGenotypeOverweight

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.017

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.315
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations438
Published2012
Admission routes2
Has abstractno

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