MétaCan
Menu
Back to cohort
Record W1989111033 · doi:10.1038/ng.2939

Low copy number of the salivary amylase gene predisposes to obesity

2014· article· en· W1989111033 on OpenAlexafffund
Mario Falchi, Julia S. El-Sayed Moustafa, Petros Takousis, Francesco Pesce, Amélie Bonnefond, Johanna C. Andersson‐Assarsson, Peter H. Sudmant, Rajkumar Dorajoo, Mashael Al‐Shafai, Leonardo Bottolo, Erdal Özdemir, Hon‐Cheong So, R. W. Davies, Alexandre Patrice, Robert Dent, Massimo Mangino, Pirro G. Hysi, Aurélie Dechaume, Marlène Huyvaert, Jane Skinner, Marie Pigeyre, Robert Caïazzo, Violeta Raverdy, Emmanuel Vaillant, Sarah Field, Beverley Balkau, Michel Marre, Sophie Visvikis‐Siest, Jacques Weill, Odile Poulain‐Godefroy, Peter Jacobson, Lars Sjöström, Christopher J. Hammond, Panos Deloukas, Pak C. Sham, Ruth McPherson, Jeannette Lee, E Shyong Tai, Robert Sladek, Lena Carlsson, Andrew J. Walley, Evan E. Eichler, François Pattou, Timothy D. Spector, Philippe Froguel

Bibliographic record

VenueNature Genetics · 2014
Typearticle
Languageen
FieldMedicine
TopicPancreatic function and diabetes
Canadian institutionsMcGill University and Génome Québec Innovation CentreMcGill UniversityOttawa HospitalMcGill Genome CentreUniversity of Ottawa
FundersNational Human Genome Research InstituteCanadian Institutes of Health ResearchNovartis PharmaNational Institutes of HealthHospital for Sick ChildrenOntario Ministry of Research and InnovationCentre National de la Recherche ScientifiqueStiftelsen för Strategisk ForskningInstitut National de la Santé et de la Recherche MédicaleKing's College LondonAssociation Diabète Risque VasculaireFédération Française de CardiologieBritish Skin FoundationFondation de FranceNovo NordiskNational Institute for Health and Care ResearchAustralian GovernmentAgence Nationale de la RechercheBiotechnology and Biological Sciences Research CouncilImperial College Healthcare NHS TrustWellcome TrustOntario GenomicsCentre Hospitalier Universitaire de RennesEli Lilly and CompanyGenome CanadaOntario Innovation TrustVetenskapsrådetBrigham and Women's HospitalDirectorate for Biological SciencesImperial College LondonMedical Research CouncilLes Laboratories Pierre FabreQatar FoundationNational Institute of General Medical SciencesEuropean Renal Association-European Dialysis and Transplant AssociationCentre hospitalier régional universitaire de LilleOntario Genomics InstituteSanofi
KeywordsCopy-number variationBiologyOdds ratioObesityGeneticsAlleleBody mass indexGene dosageGenome-wide association studyGeneInternal medicineGene expressionEndocrinologySingle-nucleotide polymorphismGenotypeGenomeMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0030.001
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0070.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.256
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations263
Published2014
Admission routes2
Has abstractno

Explore more

Same venueNature GeneticsSame topicPancreatic function and diabetesFrench-language works237,207