Dysregulation of the endothelial cellular response to oxidative stress in cancer
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The traffic of molecules and cells across the vessel wall is gated by vascular endothelial cells. In accordance, these cells play an active role in regulating cardiovascular and systemic homeostasis and in modulating physiopathological processes such as inflammation. Dysfunction of the regulatory systems of the endothelium and its incapacity to efficiently deal with its physicochemical surrounding leads to disruption of endothelial integrity. For example, alterations of the selective endothelial cell permeability barrier are early events in the sequence of oxidative stress-mediated injury that may contribute to extravasation of circulating cancer cells. Several lines of evidence indicate that the regulation of the endothelial barrier is tightly regulated by activation of signaling pathways that converge on the regulation of actin cytoskeletal dynamics. In particular, the integrity of the endothelial layer in response to oxidative stress is tightly regulated by the balanced activation of the extracellular-signal regulated kinase (ERK) and the stress-activated protein kinase-2/p38 (SAPK2/p38) pathways. Activation of the SAPK2/p38 pathway is required to trigger actin polymerization, whereas activation of the ERK pathway by contributing to phosphorylate tropomyosin-1 triggers the formation of focal adhesions allowing the anchorage of actin filaments generated by SAPK2/p38 to bundle into stress fibers. Dysregulation of this equilibrium by inhibiting ERK leads to membrane blebbing, an early manifestation of oxidative toxicity that is associated with disruption of the endothelial layer integrity.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it