NICE uses wrong comparator to assess cost effectiveness of new drugs, report says
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Patients may be denied access to new drugs and medical innovation may be stalled by the way the National Institute for Health and Care Excellence assesses medicines for cost effectiveness, a report from the University College London School of Pharmacy has claimed.1 Licensed to Cure? said that in around a quarter of the cost effectiveness assessments of new medicines that NICE carried out from 2008 to the end of 2013 the manufacturers were asked to provide data on a non-licensed alternative against which their product could be compared. David Taylor, one of the authors of the report, said that the use of low cost non-licensed medicines as comparators was wrong and could create a false perception of the true value of a new medicine. “If you were to compare the cost of a new Volvo against an old banger, it’s very unlikely the Volvo would …
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it