From Molecules to Behavior: Organismal-Level Regulation of Ion Channel Trafficking
Bibliographic record
Abstract
Transmembrane proteins are critical, not only for cell survival,but also for a myriad of physiological functions in multicellularorganisms. It is therefore necessary to have mechanisms thatregulate the number of these proteins present on the cellularmembrane at any given time. One such mechanism involvesprotein trafficking, or constitutive cycling, in which transmembraneproteins are continuously transferred between a pool locatedwithin the endoplasmic reticulum and the membrane surface byshuttle proteins (Figure 1) [1]. The actual number of proteins atthe membrane surface is controlled by the rate of exocytosis (i.e.,the rate at which proteins are inserted into the membrane) as wellas the rate of endocytosis (i.e., the rate at which proteins areremoved from the membrane). A higher rate of exocytosis willincrease the number of proteins at the membrane surface, whereasa lower rate of exocytosis will decrease that number [1–3].
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".