From Molecules to Behavior: Organismal-Level Regulation of Ion Channel Trafficking
Bibliographic record
Abstract
Transmembrane proteins are critical, not only for cell survival, but also for a myriad of physiological functions in multicellular organisms. It is therefore necessary to have mechanisms that regulate the number of these proteins present on the cellular membrane at any given time. One such mechanism involves protein trafficking, or constitutive cycling, in which transmembrane proteins are continuously transferred between a pool located within the endoplasmic reticulum and the membrane surface by shuttle proteins (Figure 1) [1]. The actual number of proteins at the membrane surface is controlled by the rate of exocytosis (i.e., the rate at which proteins are inserted into the membrane) as well as the rate of endocytosis (i.e., the rate at which proteins are removed from the membrane). A higher rate of exocytosis will increase the number of proteins at the membrane surface, whereas a lower rate of exocytosis will decrease that number [1]–[3]. Figure 1 Schematic diagram of the processes involved in the trafficking of transmembrane proteins using ion channels as a example.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".