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Record W2012110426 · doi:10.1053/j.gastro.2012.09.031

Challenges to the Design, Execution, and Analysis of Randomized Controlled Trials for Inflammatory Bowel Disease

2012· review· en· W2012110426 on OpenAlexaff
Geert D’Haens, Brian G. Feagan, Jean–Frédéric Colombel, William J. Sandborn, Walter Reinisch, Paul Rutgeerts, F. Carbonnel, Jean‐Yves Mary, Silvio Danese, Richard N. Fedorak, Steven Hanauer, Marc Lémann

Bibliographic record

VenueGastroenterology · 2012
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsUniversity of AlbertaRobarts Clinical TrialsWestern University
FundersJanssen PharmaceuticalsGenentechTillotts PharmaVifor PharmaFerring PharmaceuticalsZalicusOptimer PharmaceuticalsOtsuka AmericaUCBSchering-PloughBoehringer IngelheimTakeda Pharmaceutical CompanyNovartisCelgeneNovo NordiskJohnson and JohnsonTeva Pharmaceutical IndustriesGilead SciencesProcter and GambleRocheOrexigen TherapeuticsMerckGlaxoSmithKlinePfizerShireAstraZenecaEli Lilly and CompanyBristol-Myers SquibbDr. Falk PharmaAbbott Laboratories
KeywordsInflammatory bowel diseaseMedicineRandomized controlled trialDiseaseIntensive care medicineInflammatory Bowel DiseasesInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.481
metaresearch head score (Gemma)0.615
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.519
Threshold uncertainty score0.639

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.4810.615
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0230.008
Bibliometrics0.0040.004
Science and technology studies0.0020.011
Scholarly communication0.0140.009
Open science0.0120.006
Research integrity0.0090.022
Insufficient payload (model declined to judge)0.0050.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.059
GPT teacher head0.324
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations54
Published2012
Admission routes1
Has abstractno

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