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A novel Alzheimer disease locus located near the gene encoding tau protein
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
Bibliographic record
VenueMolecular Psychiatry · 2015
Typearticle
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsOccupational Cancer Research CentreMcGill University and Génome Québec Innovation CentreUniversity of Toronto
FundersNational Center for Research ResourcesNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesAlzheimer's Research TrustNational Cancer InstituteNational Institute of Biomedical Imaging and BioengineeringNational Human Genome Research InstituteNational Institute of Mental HealthNational Institute on AgingSynarcInstituto de Salud Carlos IIIMenzies Centre for Australian Studies, King's College London, University of LondonUniversity of California, DavisNational Institutes of HealthBijzonder Onderzoeksfonds UGentInstituut Born-BungeCentre for Medical Systems BiologyHjartaverndMarcus och Amalia Wallenbergs minnesfondElanJunta de AndalucíaUniversity of California, IrvineErasmus Medisch CentrumUniversity College London Hospitals NHS Foundation TrustMutuelle Générale de l'Education NationaleAgence Française de Sécurité Sanitaire des Produits de SantéMedical Research CouncilSwedish Brain PowerCorporación Tecnológica de AndalucíaNational Heart, Lung, and Blood InstituteNovartisNederlandse Organisatie voor Wetenschappelijk OnderzoekNorth Bristol NHS TrustDana FoundationVetenskapsrådetKuopion Yliopistollinen SairaalaKarolinska InstitutetFonds Wetenschappelijk OnderzoekAlzheimer's SocietyStichting MS ResearchFondation pour la Recherche MédicaleMedpaceNational Center for Advancing Translational SciencesBundesministerium für Bildung und ForschungUniversitat de BarcelonaAcademy of FinlandUniversity of CambridgeZonMwNewcastle UniversityNational Eye InstituteVlaamse regeringAlzheimer SocietyAustrian Science FundNational Institute for Health and Care ResearchCentro de Biología Molecular Severo OchoaUniversiteit AntwerpenNorthern California Institute for Research and EducationMedizinische Universität GrazFondation de FranceUniversity of PennsylvaniaU.S. Department of Veterans AffairsNational Institute on Deafness and Other Communication DisordersRush UniversityStockholms Läns LandstingUniversity of PittsburghWellcome TrustJohns Hopkins UniversityPfizerUniversity of WashingtonEmory UniversityYork UniversityVanderbilt UniversityOffice of Research and DevelopmentBelgian Federal Science Policy OfficeMassachusetts General HospitalGlaxoSmithKlineUniversity of MiamiNorthwestern UniversityGenentechAstraZenecaEuropean CommissionNational Institute of Environmental Health SciencesSchool of Medicine, Boston UniversityAlzheimer's AssociationInternationale Stichting Alzheimer OnderzoekSanofiEisaiUniversity of Southern CaliforniaMinistero della SaluteInstitut National de la Santé et de la Recherche MédicaleH. Lundbeck A/SKarl-Franzens-Universität GrazAlfried Krupp von Bohlen und Halbach-StiftungHoward Hughes Medical InstituteCardiff UniversityHersenstichtingEli Lilly and CompanyBristol-Myers Squibb
KeywordsApolipoprotein ESingle-nucleotide polymorphismGenome-wide association studyDementiaSNPGenotypeLocus (genetics)Alzheimer's diseaseGeneticsGenetic associationBiologyAlleleOncologyDiseaseInternal medicineMedicineGene
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.179
Threshold uncertainty score0.746
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.035
GPT teacher head0.305
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations309
Published2015
Admission routes2
Has abstractno