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Record W2048352123 · doi:10.1007/s00439-011-1055-0

Meta-analysis of new genome-wide association studies of colorectal cancer risk

2011· review· en· W2048352123 on OpenAlexafffund
Ulrike Peters, Carolyn M. Hutter, Li Hsu, Fredrick R. Schumacher, David V. Conti, Christopher S. Carlson, Christopher K. Edlund, Robert W. Haile, Steven Gallinger, Brent W. Zanke, Mathieu Lemire, Jagadish Rangrej, Raakhee Vijayaraghavan, Andrew T. Chan, Aditi Hazra, David J. Hunter, Jing Ma, Charles S. Fuchs, Edward L. Giovannucci, Peter Kraft, Yàn Liú, Lin Chen, Shuo Jiao, Karen W. Makar, Darin Taverna, Stephen B. Gruber, Gad Rennert, Vı́ctor Moreno, Cornelia M. Ulrich, Michael O. Woods, Roger C. Green, Patrick S. Parfrey, Ross L. Prentice, Charles Kooperberg, Rebecca D. Jackson, Andrea Z. LaCroix, Bette J. Caan, Richard B. Hayes, Sonja I. Berndt, Stephen J. Chanock, Robert E. Schoen, Jenny Chang‐Claude, Michael Hoffmeister, Hermann Brenner, Bernd Frank, Stéphane Bezieau, Sébastien Küry, Martha L. Slattery, John L. Hopper, Mark A. Jenkins, Loı̈c Le Marchand, Noralane M. Lindor, Polly A. Newcomb, Daniela Seminara, Thomas J. Hudson, David Duggan, John D. Potter, Graham Casey

Bibliographic record

VenueHuman Genetics · 2011
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsMemorial University of NewfoundlandOntario Institute for Cancer ResearchUniversity of TorontoUniversity Health NetworkToronto General HospitalOttawa Hospital
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of General Medical SciencesNational Heart, Lung, and Blood InstituteMedical Research CouncilCanadian Institutes of Health ResearchUniversity at BuffaloNIH Clinical CenterGroupement des Entreprises Françaises dans la lutte contre le CancerCanadian Cancer Society Research InstituteDeutsche ForschungsgemeinschaftUniversity of PittsburghConseil Régional des Pays de la LoireWellcome TrustInstitute of GeneticsUniversity of CincinnatiAssociation Anne de Bretagne GenetiqueNational Institute on AgingHealth Science Center, University of TennesseeDivision of Cancer Prevention, National Cancer InstituteUniversity of MinnesotaNational Cancer InstituteWake Forest UniversityGeorge Washington UniversityNorthwestern UniversityUniversity of MiamiUniversity of North Carolina at Chapel HillBrigham and Women's HospitalKaiser PermanenteEmory UniversityBrown UniversityOhio State UniversityUniversity of Nevada, RenoNational Institutes of HealthU.S. Department of Health and Human ServicesWomen's Health InitiativeNational Human Genome Research InstituteWayne State University
KeywordsGenome-wide association studyColorectal cancerSingle-nucleotide polymorphismBiologyOdds ratioMeta-analysisGeneticsGenetic associationSNPOncologyCancerBioinformaticsInternal medicineMedicineGenotypeGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.009
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.009
Threshold uncertainty score0.048

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0090.013
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0070.006
Bibliometrics0.0030.005
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.202
GPT teacher head0.397
Teacher spread0.195 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations208
Published2011
Admission routes2
Has abstractno

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