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Record W2052710970 · doi:10.1038/leu.2012.100

Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis

2012· review· en· W2052710970 on OpenAlexaff
Raymond L. Comenzo, Donna Reece, Giovanni Palladini, David C. Seldin, Vaishali Sanchorawala, Heather Landau, Rodney H. Falk, Karen Wells, Alina Solomon, Ashutosh Wechalekar, Jeff Zonder, Angela Dispenzieri, Morie A. Gertz, Howard Streicher, M Skinner, Robert A. Kyle, Giampaolo Merlini

Bibliographic record

VenueLeukemia · 2012
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAmyloidosis: Diagnosis, Treatment, Outcomes
Canadian institutionsPrincess Margaret Cancer Centre
FundersNational Cancer InstituteAmyloidosis Foundation
KeywordsClinical trialAL amyloidosisAmyloidosisMedicineDrug developmentClinical researchConsensus conferenceIntensive care medicineMedical physicsPathologyImmunoglobulin light chainImmunologyDrugInternal medicinePharmacologyAntibody

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.165
metaresearch head score (Gemma)0.224
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Reporting · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.835
Threshold uncertainty score0.874

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1650.224
Meta-epidemiology (narrow)0.0040.003
Meta-epidemiology (broad)0.0160.021
Bibliometrics0.0100.009
Science and technology studies0.0030.005
Scholarly communication0.0110.005
Open science0.0170.006
Research integrity0.0170.014
Insufficient payload (model declined to judge)0.0100.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.507
GPT teacher head0.533
Teacher spread0.026 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainReporting
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations383
Published2012
Admission routes1
Has abstractno

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