Abstract B98: Induction of metabolic and oxidative stresses by the novel inhibitor of NAD+ biosynthesis, GMX 1778, for specific killing of human glioblastomas
Bibliographic record
Abstract
Abstract Cancer therapy strategies that selectively target tumors while sparing normal tissues would provide enormous clinical benefit to cancer patients. Central to developing these strategies is identification of tumor specific vulnerabilities and molecular targeted agents targeting these vulnerabilities. GMX1777/1778, a novel inhibitor of NAD+ biosynthesis, is a potent and specific inhibitor of the nicotinamide adnine dinucleotide (NAD+) biosynthesis enzyme, phosphoribosyl transferase (NAMPRT). Since cancer cells have a high rate of NAD+ turnover, modulation of NAD+ biosynthesis would be an attractive target for GMX 1777/1778. In addition to the depletion of NAD+ level, we present evidence of inducing other metabolic and oxidative stresses in a tumor specific manner with minimal damage to normal tissues in vitro and in vivo. Taken together, the cancer therapeutic strategy presented here would provide a novel way of specific killing of tumors. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):B98.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".