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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
Bibliographic record
VenueNature Genetics · 2011
Typearticle
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsLunenfeld-Tanenbaum Research InstituteOntario Institute for Cancer ResearchMemorial University of Newfoundland
FundersNational Institute of Child Health and Human DevelopmentNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Allergy and Infectious DiseasesNational Human Genome Research InstituteNational Institute of Mental HealthNational Institute on AgingMünchner Zentrum für GesundheitswissenschaftenHelmholtz Zentrum MünchenTartu ÜlikoolMedical Research CouncilCanadian Cancer Society Research InstituteNational Institutes of HealthHjartaverndHealthwayTaysNovo Nordisk FondenAstraZenecaEuropean CommissionInternational Osteoporosis FoundationSydäntutkimussäätiöUniversitair Medisch Centrum GroningenAsthma and Lung UKVetenskapsrådetNederlandse Organisatie voor Wetenschappelijk OnderzoekEast Midlands Development AgencyNovo NordiskCambridge University HospitalsBritish Heart FoundationBundesministerium für Bildung und ForschungUniversity of CambridgeZonMwNational Health and Medical Research CouncilOulun YliopistoSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungRoyal SocietyUniversity of LeicesterErasmus Medisch CentrumNational Science FoundationBritish Lung FoundationNational Heart, Lung, and Blood InstituteBiotechnology and Biological Sciences Research CouncilNational Cancer InstituteAXA Research FundCancer Research UKWellcome TrustNorges Teknisk-Naturvitenskapelige UniversitetEuropean Regional Development FundKing's College LondonJalmari ja Rauha Ahokkaan SäätiöU.S. Public Health ServiceFoundation for Cardiovascular ResearchNational Eye InstituteBiocenter, University of OuluNational Institute for Health and Care ResearchFlight Attendant Medical Research InstituteNational Center for Research ResourcesNierstichtingUniversity of BristolDirectorate for Biological SciencesGlaxoSmithKlineCanadian Institutes of Health ResearchJuvenile Diabetes Research Foundation International
KeywordsGenome-wide association studyPulmonary function testingVital capacityBiologyAirway obstructionLungLung functionGeneticsBioinformaticsInternal medicineMedicineSingle-nucleotide polymorphismGenotypeAirwayGeneDiffusing capacity
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.018
Threshold uncertainty score0.766
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.012
GPT teacher head0.264
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations416
Published2011
Admission routes2
Has abstractno