Early Life Stress Induces Both Acute and Chronic Colonic Barrier Dysfunction
Bibliographic record
Abstract
Exposure to stress in early life can have a profound impact on health in later life, including intestinal pathology. Maternal separation is a well-established and reproducible model of early life stress in rodents that leads to the development of mood disorders and altered intestinal function, including visceral hypersensitivity, colonic dysmotility, and increased intestinal permeability. In this article, we highlight the consequences of disruption of normal programming after exposure to maternal separation in neonates: the development of intestinal alterations in both neonatal and adult animals as well as the accompanying behavioral changes. Mechanisms of action include corticotropin-releasing factor (CRF) and nerve growth factor (NGF), which signal both in the brain and in the periphery. Exposure to stress in early life also can alter bacterial colonization, which is prevented by treatment with probiotic organisms. We conclude by highlighting the link between stress and colonic permeability in humans, including the increased risk of disease relapse in irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".