Cytobots: intracellular robotic micromanipulators
Bibliographic record
Abstract
A cytobot is an intracellular robotic micromanipulator, a microfabricated device small enough to be introduced into a cell. Control for a cytobot can be accomplished using three mutually perpendicular sequential magnetic control systems along with an electromechanical stepper microscope stage. Control depends on viscous damping within the cell. The design and fabrication techniques are discussed and the processing techniques used in the fabrication of cytobots highlighted. Fabrication of various magnetic cytobots are then illustrated namely, a chisel, a "circular" saw blade, a "fishing" hook; a cuff for fibers, a box to confine an organelle, and an aspirator, and the functionality of these devices is explained. In order for the cytobot to get into the cell, it must be injected with a small needle, or since the majority of the structure is a magnet, it could be fired in ballisticly like a magnetic bullet. Once introduced into an embryonic cell one can continuously manipulate one cell of the developing organism as cell division proceeds. We also discuss the possibility of making such devices small enough to enter the cell nucleus, i.e., karyobots.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".