Cytobots: intracellular robotic micromanipulators
Bibliographic record
Abstract
A cytobot is an intracellular robotic micromanipulator, a microfabricated device small enough to be introduced into a cell. Control for a cytobot can be accomplished using three mutually perpendicular sequential magnetic control systems along with an electromechanical stepper microscope stage. Control depends on viscous damping within the cell. The design and fabrication techniques are discussed and the processing techniques used in the fabrication of cytobots highlighted. Fabrication of various magnetic cytobots are then illustrated namely, a chisel, a "circular" saw blade, a "fishing" hook; a cuff for fibers, a box to confine an organelle, and an aspirator, and the functionality of these devices is explained. In order for the cytobot to get into the cell, it must be injected with a small needle, or since the majority of the structure is a magnet, it could be fired in ballisticly like a magnetic bullet. Once introduced into an embryonic cell one can continuously manipulate one cell of the developing organism as cell division proceeds. We also discuss the possibility of making such devices small enough to enter the cell nucleus, i.e., karyobots.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".