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Epigenetics and the Biological Definition of Gene × Environment Interactions

2010· review· en· 1,218 citations· W2128782957 on OpenAlex· 10.1111/j.1467-8624.2009.01381.x

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Theoretical or conceptualNot applicable
Classifier consensus
Theoretical or conceptual
Teacher imitation scores

Codex

Other design0.994
Theoretical or conceptual0.028
Systematic review0.004
Observational0.001
Bench or experimental0.001
Research integrity0.001
Not applicable0.001
Metaresearch0.001
Science and technology studies0.001
Bibliometrics0.000
Meta-analysis0.000
Meta-epidemiology (broad)0.000
Qualitative0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Non-randomized trial0.000
Simulation or modelling0.000
Scholarly communication0.000
Randomized trial0.000

Gemma

Not applicable0.539
Theoretical or conceptual0.038
Observational0.031
Systematic review0.027
Research integrity0.002
Bench or experimental0.001
Meta-epidemiology (broad)0.001
Metaresearch0.000
Bibliometrics0.000
Science and technology studies0.000
Open science0.000
Meta-analysis0.000
Case report0.000
Qualitative0.000
Meta-epidemiology (narrow)0.000
Non-randomized trial0.000
Simulation or modelling0.000
Scholarly communication0.000
Randomized trial0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.089
GPT teacher head0.323
Teacher spread
0.234 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.

Retrieved from PubMed through NCBI EFetch. Structured section labels are preserved.