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Record W2143350483 · doi:10.1038/ng.3176

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

2015· article· en· W2143350483 on OpenAlexaff
Philippe Goyette, Gabrielle Boucher, Dermot Mallon, Eva Ellinghaus, Luke Jostins, Hailiang Huang, Stephan Ripke, Elena S. Gusareva, Vito Annese, Stephen L. Hauser, Jorge R. Oksenberg, Ingo Thomsen, Stephen Leslie, Mark J. Daly, Kristel Van Steen, Richard H. Duerr, Jeffrey C. Barrett, Dermot McGovern, L. Philip Schumm, James A. Traherne, Mary Carrington, Vasilis Kosmoliaptsis, Tom H. Karlsen, André Franke, John D. Rioux

Bibliographic record

VenueNature Genetics · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsUniversité de MontréalMontreal Heart Institute
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Allergy and Infectious DiseasesNational Center for Advancing Translational SciencesLeona M. and Harry B. Helmsley Charitable TrustMedical Research CouncilNational Cancer InstituteNational Institute of Dental and Craniofacial ResearchSeventh Framework ProgrammeExzellenzclusters EntzündungsforschungAgency for Healthcare Research and QualityCrohn's and Colitis UKNational Institute for Health and Care ResearchBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftInstitut National Du CancerNational Health and Medical Research CouncilNIHR Cambridge Biomedical Research CentreMultiple Sclerosis SocietyAcademy of Medical SciencesNational Institute of Neurological Disorders and StrokeUniversity of PittsburghWellcome TrustFrederick National Laboratory for Cancer ResearchEuropean CommissionNational Institutes of HealthU.S. Department of Health and Human Services
KeywordsUlcerative colitisBiologyInflammatory bowel diseaseHuman leukocyte antigenInflammatory Bowel DiseasesMajor histocompatibility complexImmunologyGeneticsInternal medicineAntigenDiseaseMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.058
Threshold uncertainty score0.744

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.236
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations379
Published2015
Admission routes1
Has abstractno

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