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Record W2151389489 · doi:10.1093/jnci/dji354

Approaches Vary for Clinical Trials in Developing Countries

2005· article· en· W2151389489 on OpenAlexaboutno aff
Elana Hayasaka

Bibliographic record

VenueJNCI Journal of the National Cancer Institute · 2005
Typearticle
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineClinical trialDeveloping countryIntensive care medicineBiologyInternal medicine

Abstract

fetched live from OpenAlex

In a hospital in Morocco, cancer patients must wait 2 or 3 days for a bed to open up. In a Guatemalan health center, two harried clinicians juggle all of the more than 400 new cases of leukemia each year. In some places in India, 60%–70% of cancer patients are turned away from hospitals because of a lack of medical resources. “Clinical trials? Wouldn't [providing] soap be a better place to start?” Ronald Barr , M.D., of McMaster University in Canada, said of conducting clinical trials in developing countries, only half joking. He remembers handing out blocks of soap to doctors in Kenya, who gave the precious bars to parents as an incentive not to abandon their sick children in hospitals. “There are huge fundamental challenges that need to be addressed before you can think about doing trials,” he added. Researchers at pharmaceutical companies and academic institutions and organizations are addressing these challenges head-on as interest grows in conducting clinical trials in developing regions, whether for humanitarian reasons, furthering scientific knowledge, or economic savings. However, opinions differ as to the types of trials needed and how such trials should be conducted.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.231
metaresearch head score (Gemma)0.267
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.769
Threshold uncertainty score0.948

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2310.267
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0020.003
Bibliometrics0.0040.005
Science and technology studies0.0050.020
Scholarly communication0.0270.021
Open science0.0060.017
Research integrity0.0170.034
Insufficient payload (model declined to judge)0.0360.023

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.911
GPT teacher head0.615
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designObservational
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations13
Published2005
Admission routes1
Has abstractyes

Explore more

Same venueJNCI Journal of the National Cancer InstituteSame topicHealth Systems, Economic Evaluations, Quality of LifeFrench-language works237,207