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Record W2152061559 · doi:10.1038/nature12477

Signatures of mutational processes in human cancer

2013· article· en· W2152061559 on OpenAlexafffund
Ludmil B. Alexandrov, Serena Nik‐Zainal, David C. Wedge, Samuel Aparício, Sam Behjati, Andrew V. Biankin, Graham R. Bignell, Niccolò Bolli, Åke Borg, Anne‐Lise Børresen‐Dale, Sandrine Boyault, Birgit Burkhardt, Adam P. Butler, Carlos Caldas, Helen Davies, Christine Desmedt, Roland Eils, Jórunn E. Eyfjörd, John A. Foekens, Mel Greaves, Fumie Hosoda, Barbara Hutter, Tomislav Ilicic, Sandrine Imbeaud, Marcin Imieliński, Natalie Jäger, David Jones, David R. Jones, Stian Knappskog, Marcel Kool, Sunil R. Lakhani, Carlos López-Otı́n, Sancha Martin, Nikhil C. Munshi, Hiromi Nakamura, Paul A. Northcott, Marina Pajic, Elli Papaemmanuil, Angelo Paradiso, John V. Pearson, Xosé S. Puente, Keiran Raine, Manasa Ramakrishna, Andrea L. Richardson, Julia Richter, Philip Rosenstiel, Matthias Schlesner, Ton N. Schumacher, Paul N. Span, Jon W. Teague, Yasushi Totoki, Andrew Tutt, Rafael Valdés‐Mas, Marit M. van Buuren, Laura van ‘t Veer, Anne Vincent‐Salomon, Nicola Waddell, Lucy Yates, Jessica Zucman‐Rossi, P. Andrew Futreal, Ultan McDermott, Peter Lichter, Matthew Meyerson, Sean M. Grimmond, Reiner Siebert, Elı́as Campo, Tatsuhiro Shibata, Stefan M. Pfister, Peter J. Campbell, Michael R. Stratton

Bibliographic record

VenueNature · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer Genomics and Diagnostics
Canadian institutionsUniversity of British ColumbiaUniversity of British Columbia HospitalCanada's Michael Smith Genome Sciences CentreBC Cancer Agency
FundersCancer Research UK Cambridge Institute, University of CambridgeNational Cancer InstituteLabex Immuno-OncologyBC Cancer AgencyMedisinske fakultet, Universitetet i OsloUniversitat de BarcelonaHáskóli ÍslandsUniversitetet i OsloUniversity of GlasgowInstitut National de la Santé et de la Recherche MédicaleWellcome TrustAgence Nationale de la RechercheCancer Research UKBroad InstituteUniversity of New South WalesCanada's Michael Smith Genome Sciences CentreLunds UniversitetDeutsches Krebsforschungszentrum
KeywordsCancerComputational biologyHuman genomeBiologyGeneticsGenomeGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.269
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10,140
Published2013
Admission routes2
Has abstractno

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