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Record W2154403718 · doi:10.1126/science.1133609

The Genome of the Sea Urchin <i>Strongylocentrotus purpuratus</i>

2006· article· en· W2154403718 on OpenAlexaff
Erica Sodergren, George M. Weinstock, Eric H. Davidson, R. Andrew Cameron, Richard A. Gibbs, Robert C. Angerer, Lynne M. Angerer, Maria Ina Arnone, David R. Burgess, Robert D. Burke, James A. Coffman, Michael Dean, Maurice R. Elphick, Charles A. Ettensohn, Kathy R. Foltz, Amro Hamdoun, Richard O. Hynes, William H. Klein, William F. Marzluff, David R. McClay, Robert L. Morris, Arcady Mushegian, Jonathan P. Rast, L. Courtney Smith, Michael C. Thorndyke, Victor D. Vacquier, Gary M. Wessel, Greg Wray, Lan Zhang, Christine G. Elsik, Olga Ermolaeva, Wratko Hlavina, Gretchen E. Hofmann, Paul Kitts, Melissa Landrum, Aaron J. Mackey, Donna Maglott, G. V. Panopoulou, Albert J. Poustka, Kim D. Pruitt, Victor Sapojnikov, Xingzhi Song, Alexandre Souvorov, Victor Solovyev, Wei Zheng, Charles A. Whittaker, Kim C. Worley, K. James Durbin, Yufeng Shen, Olivier Fédrigo, David Garfield, Ralph Haygood, Alexander Primus, Rahul Satija, Tonya F. Severson, Manuel L. Gonzalez‐Garay, Andrew R. Jackson, Aleksandar Milosavljevic, Mark Tong, Christopher E. Killian, Brian T. Livingston, Fred H. Wilt, Nikki Adams, Robert Bellé, Seth Carbonneau, Rocky Cheung, Patrick Cormier, Bertrand Cosson, Jenifer C. Croce, Antonio Fernàndez-Guerra, Anne-Marie Genevière, Manisha Goel, Hemant Kelkar, Julia Morales, Odile Mulner‐Lorillon, A Robertson, Jared V. Goldstone, Bryan J. Cole, David Epel, Bert Gold, Mark E. Hahn, Meredith Ashby, Mark Scally, John J. Stegeman, Erin L. Allgood, Jonah Cool, Kyle M. Judkins, S. Shawn McCafferty, Ashlan M. Musante, Robert A. Obar, Amanda P. Rawson, Blair J. Rossetti, I. R. Gibbons, Matthew P. Hoffman, Andrew Leone, Sorin Istrail, Stefan C. Materna, Manoj P. Samanta, Viktor Štolc, Waraporn Tongprasit, Qiang Tu, Karl‐F. Bergeron, Bruce P. Brandhorst, James R. Whittle, Kevin Berney, David J. Bottjer, Cristina Calestani, Kevin J. Peterson, Elly Suk Hen Chow, Qiu Autumn Yuan, Eran Elhaik, Dan Graur, Justin Reese, Ian Bosdet, Heesun Shin, Marco A. Marra, Jacqueline E. Schein, Michele K. Anderson, Virginia Brockton, Katherine M. Buckley, Avis H. Cohen, Sebastian D. Fugmann, Taku Hibino, Mariano Loza‐Coll, Audrey J. Majeske, Cynthia Messier, Sham V. Nair, Zeev Pancer, David P. Terwilliger, Cavit Ağca, Enrique Arboleda, Nansheng Chen, Allison Churcher, F. Hallböök, Glen Humphrey, Mohammed M. Idris, Takae Kiyama, Shuguang Liang, Dan O Mellott, Xiuqian Mu, Greg Murray, Robert P. Olinski, Florian Raible, Matthew L. Rowe, John S. Taylor, Kristin Tessmar‐Raible, D. Wang, Karen Wilson, Shunsuke Yaguchi, Terry Gaasterland, Blanca E. Galindo, Herath Jayantha Gunaratne, Celina E. Juliano, Masashi Kinukawa, Gary W. Moy, Anna T. Neill, Mamoru Nomura, Michael Raisch, Anna Reade, Michelle M. Roux, Jia L. Song, Yi‐Hsien Su, Ian K. Townley, Ekaterina Voronina, Julian L. Wong, Gabriele Amore, Margherita Branno, Euan R. Brown, Vincenzo Cavalieri, Véronique Duboc, Louise Duloquin, Constantin N. Flytzanis, Christian Gache, François Lapraz, Thierry Lepage, Annamaria Locascio, Pedro Martı́nez, Giorgio Matassi, Valeria Matranga, Ryan Range, Francesca Rizzo, Eric Röttinger, Wendy S. Beane, Cynthia A. Bradham, Christine A. Byrum, Tom Glenn, Sofia Hussain, Gerard Manning, Esther Miranda, Rebecca T. Thomason, Katherine D. Walton, Athula Wikramanayke, Shu-Yu Wu, Ronghui Xu, C. Titus Brown, Li-Li Chen, Rachel F. Gray, Pei Yun Lee, Jongmin Nam, Paola Oliveri, Joel Smith, Donna M. Muzny, Stephanie Bell, Joseph Chacko, Andrew Cree, Stacey Curry, Clay Davis, Huyen Dinh, Shannon Dugan-Rocha, Jerry Fowler, Rachel Gill, Cerrissa Hamilton, Judith Hernandez, Sandra Hines, Jennifer Hume, LaRonda Jackson, Angela Jolivet, Christie Kovar, Lora Lewis, George Miner, Margaret Morgan, Lynne V. Nazareth, Geoffrey Okwuonu, David L. Parker, Lingling Pu, R. Greg Thorn, Rita Wright

Bibliographic record

VenueScience · 2006
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicEchinoderm biology and ecology
Canadian institutionsSunnybrook Health Science CentreSimon Fraser UniversityUniversity of Victoria
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Environmental Health SciencesNational Institute on Deafness and Other Communication DisordersNational Eye InstituteNational Human Genome Research InstituteBiotechnology and Biological Sciences Research CouncilNational Center for Research ResourcesNational Institute of General Medical SciencesDirectorate for Biological SciencesNational Cancer InstituteNational Institutes of Health
KeywordsStrongylocentrotus purpuratusBiologyGenomeSea urchinEvolutionary biologyEchinodermVertebrateGeneticsShotgun sequencingDeuterostomeChordateWhole genome sequencingComputational biologyGeneEcology

Abstract

fetched live from OpenAlex

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.003
GPT teacher head0.164
Teacher spread0.160 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,154
Published2006
Admission routes1
Has abstractyes

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