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Record W2163524749 · doi:10.1126/science.1132894

Draft Genome Sequence of the Sexually Transmitted Pathogen <i>Trichomonas vaginalis</i>

2007· article· en· W2163524749 on OpenAlexaff
Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael C. Schatz, Qi Zhao, Jennifer R. Wortman, Shelby Bidwell, U. Cecilia M. Alsmark, Sébastien Besteiro, Thomas Sicheritz‐Pontén, Christophe Noël, Joel B. Dacks, Peter G. Foster, Cédric Simillion, Yves Van de Peer, Diego Miranda‐Saavedra, Geoffrey J. Barton, Gareth D. Westrop, Sylke Müller, Daniele Dessì, Pier Luigi Fiori, Qinghu Ren, Ian T. Paulsen, Hanbang Zhang, Felix Bastida, Augusto Simões-Barbosa, Mark T. Brown, Richard D. Hayes, Mandira Mukherjee, Cheryl Okumura, Rachel Schneider, Alias Smith, Maria Villalvazo, Brian J. Haas, Mihaela Pertea, Tamara V. Feldblyum, Terry Utterback, Chung-Li Shu, Kazutoyo Osoegawa, Pieter J. de Jong, Ivan Hrdý, Lenka Horváthová, Zuzana Zubáčová, Pavel Doležal, Shehre-Banoo Malik, John M. Logsdon, Katrin Henze, Arti Gupta, Ching C. Wang, Rebecca Dunne, Jacqueline Upcroft, Peter Upcroft, Owen White, Steven L. Salzberg, Petrus Tang, Cheng‐Hsun Chiu, Ying‐Shiung Lee, T. Martin Embley, Graham H. Coombs, Jeremy C. Mottram, Jan Tachezy, Claire M. Fraser, Patricia J. Johnson

Bibliographic record

VenueScience · 2007
Typearticle
Languageen
FieldImmunology and Microbiology
TopicParasitic Infections and Diagnostics
Canadian institutionsUniversity of Calgary
FundersNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthU.S. National Library of MedicineChang Gung Medical FoundationUniversity of GlasgowDirectorate for Biological SciencesDanmarks Tekniske UniversitetEuropean Molecular Biology LaboratoryWellcome TrustEllison Medical Foundation
KeywordsBiologyGenomeTrichomonas vaginalisGeneticsTrichomonasGeneTransposable elementWhole genome sequencingHorizontal gene transfer

Abstract

fetched live from OpenAlex

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.011
Threshold uncertainty score0.029

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0090.009

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.271
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations840
Published2007
Admission routes1
Has abstractyes

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