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The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index

2014· review· en· 736 citations· W2164957370 on OpenAlex· 10.1016/j.jclinepi.2013.10.019

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.864
GPT teacher head0.686
Teacher spread
0.178 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Journal of Clinical Epidemiology
Topic
Meta-analysis and systematic reviews
Field
Decision Sciences
Canadian institutions
University of TorontoWestern UniversityOttawa HospitalHealth Sciences CentreCanada Research ChairsUniversity of ManitobaUniversity of OttawaManitoba HealthHamilton Health SciencesLondon Health Sciences CentreMcMaster UniversityPopulation Health Research Institute
Funders
Heart and Stroke Foundation of Canada
Keywords
FragilityRandomized controlled trialStatistical significanceMedicineIndex (typography)Sample size determinationInternal medicineStatisticsMathematics
Has abstract in OpenAlex
no