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Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Lena Backlund, Cláudio E. M. Banzato, Antoni Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Armin Birner, Clara Brichant‐Petitjean, Elise T. Bui, Pablo Cervantes, Guo‐Bo Chen, Hsi‐Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Francesc Colom, David A. Cousins, Cristiana Cruceanu, Piotr M. Czerski, Clarissa de Rosalmeida Dantas, Alexandre Dayer, Bruno Étain, Peter Falkai, Andreas J. Forstner, Louise Frisén, Janice M. Fullerton, Sébastien Gard, Julie Garnham, Fernando S. Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Stéphane Jamain, Esther Jiménez, Jean‐Pierre Kahn, Layla Kassem, Sarah Kittel‐Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Carlos López‐Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J. McCarthy, Susan L. McElroy, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Urban Ösby, Norio Ozaki, Roy H. Perlis, Andrea Pfennig, Daniela Reich‐Erkelenz, Guy A. Rouleau, Peter R. Schofield, Klaus Oliver Schubert, Barbara Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Kazutaka Shimoda, Christian Simhandl, Claire Slaney, Jordan W. Smoller, Alessio Squassina, Thomas Stamm, Pavla Stopková, Sarah K. Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie H. Witt, A. Jordan Wright, L. Trevor Young, Peter P. Zandi, James B. Potash, J. Raymond DePaulo, Michael Bauer, Eva Z. Reininghaus, Tomáš Novák, Jean-Michel Aubry, Mario Maj, Bernhard T. Baune, Philip B. Mitchell, Eduard Vieta, Mark A. Frye, Janusz Rybakowski, Po‐Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu‐Serbânescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R. Wray, John R. Kelsoe, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze
Bibliographic record
VenueThe Lancet · 2016
Typearticle
Languageen
FieldMedicine
TopicBipolar Disorder and Treatment
Canadian institutionsUniversity of CalgaryMcGill UniversityDouglas Mental Health University InstituteMcGill University Health CentreUniversity of TorontoDalhousie UniversityMontreal Neurological Institute and Hospital
FundersNational Institute of Mental HealthNational Health and Medical Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchEli Lilly JapanNational Institutes of HealthRheinische Friedrich-Wilhelms-Universität BonnCentro de Investigación Biomédica en Red de Salud MentalAlfried Krupp von Bohlen und Halbach-StiftungEli Lilly and CompanyLundbeckfondenBundesministerium für Bildung und ForschungUniversity of OxfordUniversity of New South WalesSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungFondation FondaMentalBroad InstituteJ. Willard and Alice S. Marriott FoundationNational Cancer InstituteServierGilead SciencesVirginia Commonwealth UniversityNational Institute on Drug AbuseStanley Center for Psychiatric Research, Broad InstituteNovo NordiskUniversity of PennsylvaniaDeutsche ForschungsgemeinschaftUniversity of LouisvilleGlaxoSmithKlineOrexigen TherapeuticsJohns Hopkins UniversityDainippon Sumitomo PharmaMinistry of Education, IndiaPfizerRush UniversityWayne State UniversityH. Lundbeck A/SSunovionNational Science Foundation
KeywordsGenome-wide association studyBipolar disorderGenetic associationLithium (medication)Association (psychology)GeneticsMedicineBiologyComputational biologyPsychiatrySingle-nucleotide polymorphismPsychologyGenotypeGenePsychotherapist
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.026
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.017
GPT teacher head0.263
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations400
Published2016
Admission routes2
Has abstractno