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Record W2262279506 · doi:10.1016/s0140-6736(16)00143-4

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

2016· article· en· W2262279506 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueThe Lancet · 2016
Typearticle
Languageen
FieldMedicine
TopicBipolar Disorder and Treatment
Canadian institutionsUniversity of CalgaryMcGill UniversityDouglas Mental Health University InstituteMcGill University Health CentreUniversity of TorontoDalhousie UniversityMontreal Neurological Institute and Hospital
FundersNational Institute of Mental HealthNational Health and Medical Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchEli Lilly JapanNational Institutes of HealthRheinische Friedrich-Wilhelms-Universität BonnCentro de Investigación Biomédica en Red de Salud MentalAlfried Krupp von Bohlen und Halbach-StiftungEli Lilly and CompanyLundbeckfondenBundesministerium für Bildung und ForschungUniversity of OxfordUniversity of New South WalesSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungFondation FondaMentalBroad InstituteJ. Willard and Alice S. Marriott FoundationNational Cancer InstituteServierGilead SciencesVirginia Commonwealth UniversityNational Institute on Drug AbuseStanley Center for Psychiatric Research, Broad InstituteNovo NordiskUniversity of PennsylvaniaDeutsche ForschungsgemeinschaftUniversity of LouisvilleGlaxoSmithKlineOrexigen TherapeuticsJohns Hopkins UniversityDainippon Sumitomo PharmaMinistry of Education, IndiaPfizerRush UniversityWayne State UniversityH. Lundbeck A/SSunovionNational Science Foundation
KeywordsGenome-wide association studyBipolar disorderGenetic associationLithium (medication)Association (psychology)GeneticsMedicineBiologyComputational biologyPsychiatrySingle-nucleotide polymorphismPsychologyGenotypeGenePsychotherapist

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.017
Threshold uncertainty score0.344

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.263
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it