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A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease
Megan Hardin, Min Hyun Cho, Eric Yuk Fai Wan, David A. Lomas, Harvey O. Coxson, Jørgen Vestbo, Julie Yates, Àlvar Agustí, Peter Calverley, B Celli, Courtney Crim, Stephen I. Rennard, Emiel F.�M. Wouters, Surya P. Bhatt, Victor Kim, Joe Ramsdell, E.A. Regan, Barry J. Make, John E. Hokanson, James D. Crapo, Terri H. Beaty, C.P. Hersh, Edwin K. Silverman, Elizabeth A. Regan, Nan M. Laird, Christoph Lange, Michael Cho, Stephanie A. Santorico, Dawn L. DeMeo, Nadia N. Hansel, Craig P. Hersh, Peter J. Castaldi, Merry‐Lynn McDonald, Emily S. Wan, Jacqueline B. Hetmanski, Margaret M. Parker, Marilyn G. Foreman, Brian D. Hobbs, Robert Busch, Adel El-Bouiez, Dandi Qiao, Eitan Halper‐Stromberg, Ferdouse Begum, Sungho Won, Brittney Fredericksen, Sharon M. Lutz, David A. Lynch, MeiLan K. Han, Eric A. Hoffman, Stephen M. Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, John D. Newell, James C. Ross, Raúl San Jośe Estépar, Berend C. Stoel, Juerg Tschirren, Eva M. van Rikxoort, Bram van Ginneken, Carla G. Wilson, Mustafa Al Qaisi, Teresa Gray, Alex Kluiber, Tanya Mann, Jered Sieren, Douglas R. Stinson, Joyce Schroeder, Edwin J.R. van Beek, Robert L. Jensen, D. H. Everett, Anna Faino, Matthew Strand, Jennifer L. Black‐Shinn, Gregory L. Kinney, Katherine Pratte, Jeffrey L. Curtis, Carlos José Álvarez Martínez, Perry G. Pernicano, Nicola A. Hanania, Philip Alapat, Venkata Bandi, Mustafa Atik, Aladin M. Boriek, Kalpatha Guntupalli, Elizabeth Guy, Amit Parulekar, Arun C. Nachiappan, R. Graham Barr, Byron Thomashow, John Austin, Belinda D’Souza, Gregory D. Pearson, Anna Rozenshtein, Neil R. MacIntyre, H. Page McAdams, Charlene McEvoy, Joseph Tashjian, Robert A. Wise, Robert H. Brown, Karen M. Horton, Nirupama Putcha, Richard Casaburi, Alessandra Adami, János Pórszász, Hans Fischer, Matthew J. Budoff, Dan Cannon, Harry B. Rossiter, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Gloria Westney, Eugene A. Berkowitz, Russell P. Bowler, Richard Rosiello, David Pace, Gerard J. Criner, David Ciccolella, Francis Cordova, Chandra Dass, R D'Alonzo, Parag Desai, Michael R. Jacobs, Steven G. Kelsen, A.J. Mamary, Nathaniel Marchetti, Aditti Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Gloria Vega-Sanchez, Hrudaya Nath, Mark T. Dransfield, William C. Bailey, J. Michael Wells, Paul J. Friedman, Xavier Soler, Andrew Yen, Alejandro Cornellas, Brad Thompson, Fernando D. Martínez, Joanne Billings, Tadashi Allen, Frank C. Sciurba, Divay Chandra, Joel L. Weissfeld, Carl R. Fuhrman, Jessica Bon, Antonio Anzueto, Sylvia Adams, Diego Maselli-Caceres, Mario E. Ruiz, Jean Bourbeau, Mark Fitzgerald, Pilar Hernández, K. J. Killian, Robert D. Levy, F. Maltais, D. E. O'Donnell, J. KREPELKA, David I. Quinn, Mitja Košnik, Palma de Mallorca, Y. I. Feschenko, V. Gavrisyuk, L. P. Yashina, Dave Singh, Jadwiga A. Wedzicha, S. Kristine Braman, G. Giessel, Mark H. Gotfried, Gilbert S. Greenwald, NA Hanania, D.A. Mahler, Carolyn L. Rochester, Paul Scanlon, Dan Schuller, Thomas M. Siler, Adam Wanner, Lisa Edwards, William MacNee, Bruce E. Miller, Ruth Tal‐Singer
Bibliographic record
VenueThe Pharmacogenomics Journal · 2015
Typereview
Languageen
FieldMedicine
TopicAsthma and respiratory diseases
Canadian institutionsVancouver General Hospital
FundersNational Institute of Environmental Health SciencesNational Institute for Health and Care ResearchNational Institute of Nursing ResearchMedical Research CouncilNational Institutes of HealthPfizerNational Heart, Lung, and Blood InstituteSunovionAstraZenecaCSL BehringGlaxoSmithKlineCOPD Foundation
KeywordsCOPDSingle-nucleotide polymorphismGenome-wide association studyMedicineGenetic associationInternal medicineBioinformaticsGeneticsGeneGenotypeBiology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.004
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.046
GPT teacher head0.364
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations37
Published2015
Admission routes1
Has abstractno