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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Not applicableConsensus signal: none
- Genre
- Candidate signal: ReviewConsensus signal: Review
- Teacher disagreement score
- 0.983
- Threshold uncertainty score
- 0.729
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Opus teacher head0.014
GPT teacher head0.316
- Teacher spread
- 0.302 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Nature Neuroscience
- Topic
- Genetic Associations and Epidemiology
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- not available
- Funders
- Scottish Mental Health Research NetworkNational Center for Research ResourcesNational Institute of Biomedical Imaging and BioengineeringNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Mental HealthStrategic Research CouncilNational Health and Medical Research CouncilKnut och Alice Wallenbergs StiftelseEuropean CommissionCanadian Institutes of Health ResearchAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalStanley Center for Psychiatric Research, Broad InstituteNational Institutes of HealthBiogenHøjteknologifondenRamsay Health CareH. Lundbeck A/SMedical Research CouncilAcademy of FinlandServierTartu ÜlikoolUppsala UniversitetUniversity of New South WalesRadboud Universitair Medisch CentrumUniversitair Medisch Centrum GroningenBiomedical Research CouncilUniversitetet i BergenKarolinska InstitutetLundbeckfondenAccareNational Cancer InstituteEuropean Regional Development FundMax-Planck-GesellschaftBergens ForskningsstiftelseSvenska Forskningsrådet FormasVrije Universiteit AmsterdamVetenskapsrådetUniversiteit UtrechtStockholms Läns LandstingNorges ForskningsrådNational Medical Research CouncilUniversiteit LeidenAustralian Schizophrenia Research BankNederlandse Organisatie voor Wetenschappelijk OnderzoekDeutsche ForschungsgemeinschaftGenentechBundesministerium für Bildung und ForschungMedpaceStanley Medical Research InstituteBritish Heart FoundationAgency for Science, Technology and ResearchNorthern California Institute for Research and EducationCentre d'Imagerie BioMédicaleEisaiLeids Universitair Medisch CentrumRiksbankens JubileumsfondFoundation for the National Institutes of HealthNational Alliance for Research on Schizophrenia and DepressionHersenstichtingU.S. Department of DefenseCommonwealth Scientific and Industrial Research OrganisationNational Institute for Health and Care ResearchPratt FoundationNHS Blood and TransplantSylvia and Charles Viertel Charitable FoundationSeventh Framework ProgrammeNovartis Pharmaceuticals CorporationUniversity of California, San DiegoWellcome TrustJohns Hopkins UniversityPfizerNational Institute on AgingUniversität GreifswaldAustralian Research CouncilBioClinicaUniversity of MelbourneScience for Life LaboratoryAkademiska SjukhusetHarvard UniversityBroad InstituteAustralian GovernmentF. Hoffmann-La RocheSynarcMax Planck Instituut voor PsycholinguïstiekEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUniversity of Southern CaliforniaScience Foundation IrelandNational Science FoundationScottish Funding CouncilMassachusetts General HospitalGlaxoSmithKlineRadboud UniversiteitEli Lilly and CompanyAlzheimer's Disease Neuroimaging InitiativeMax-Planck-FörderstiftungAutism SpeaksBristol-Myers SquibbIXICOAlfried Krupp von Bohlen und Halbach-StiftungAlzheimer's AssociationNational Institute of Neurological Disorders and StrokeBritish Medical AssociationU.S. Department of Veterans AffairsAarhus UniversitetMeso Scale DiagnosticsZonMwStrategiske Forskningsråd
- Keywords
- Schizophrenia (object-oriented programming)Genetic architectureHeritabilityNeuroscienceImaging geneticsGenome-wide association studyBrain sizeNeuroimagingGenetic associationGenetic correlationEndophenotypePsychologyPhenotypeGenetic variationBiologyPsychiatryGeneticsMedicineCognitionSingle-nucleotide polymorphismGeneGenotype
- Has abstract in OpenAlex
- no