Are new anthelmintics needed to eliminate human helminthiases?
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
PURPOSE OF REVIEW: Anthelmintic mass drug administration (MDA) has limited pathology and transmission of filariases, schistosomiasis and gastrointestinal nematodiases in many areas of the world. This record has led to the adoption of ambitious goals for eliminating these infections on a global scale within the next decade or two by expansion of MDA with available drugs. This review considers the attributes of anthelmintics that favor or limit attainment of the scaled-up plans for elimination, and highlights situations for which new or reformulated drugs may be needed. RECENT FINDINGS: Many challenges face elimination campaigns. Anthelmintic needs include, first, a macrofilaricidal regimen that speeds up elimination, is safe to use in regions of Onchocerca volvulus and Loa loa coendemicity, and provides a rapid method to resolve infections introduced into previously controlled areas; second, a replacement of praziquantel for schistosomiasis should a resistance arise; third, formulations of praziquantel to enhance compliance, and pediatric formulations for preschool children; fourth, a regimen that provides high efficacy against Trichuris trichiura (new anthelmintic, prolonged dosing strategy or anthelmintic combinations); fifth, pediatric formulations of albendazole and mebendazole compatible with elimination operations; and sixth, an alternative to benzimidazoles in the anticipation of the development of drug resistance. SUMMARY: Expansion of MDA programs to attain elimination of human helminthiases is a noble and worthwhile endeavor. Increased drug pressure should be expected to select resistance alleles. Alternative anthelmintics and regimens should be developed for deployment to ensure that the ambitious goals for elimination are not endangered due to an inadequate pharmacopeia.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it