Abstract 2123: Protein synthesis and its control in cancer development, progression and treatment
Bibliographic record
Abstract
Abstract A central dogma of molecular biology posits that the protein biosynthetic pathway generally follows the three major events: replication, transcription and translation. The abnormal functioning of any of these processes can nurture malignant cellular transformation. While other components of the central dogma were front-page in cancer research, translation, somewhat, remained in the shades. This presentation is based on the recently published book “Translation and Its Regulation in Cancer Biology and Medicine”* that for the first time comprehensively summarizes and analyzes decades of information into the role of the aberrations in protein synthesis, translation, as well as its regulation in the biology of cancer. The mechanisms of action of various translation factors, such as oncoprotein eIF4E, and tumor suppressors, such as PDCD4, are intensively discussed. Other, less-studied protein factors participating in the complex process of translation are presented in light of their known or emerging roles in cancer development and progression. In addition, the presentation focuses on the oncogenic role of the regulation of the translation machinery by fundamental cellular signal transduction pathways, such as mTOR, MAPK and others. Finally, clinical applications of the current knowledge regarding the translation machinery, its function and regulation in cancer are highlighted, including the use of the translation factors as diagnostic and prognostic markers, as well as factors for novel approaches to targeted pharmacologic treatment. * Translation and Its Regulation in Cancer Biology and Medicine Parsyan, Armen (Ed.) 2014, XXXIV, 697 p. 52 illus., 44 illus. in color., Hardcover ISBN 978-94-017-9078-9 Springer Publishing Website: http://www.springer.com/biomed/cancer/book/978-94-017-9077-2 Citation Format: Armen Parsyan. Protein synthesis and its control in cancer development, progression and treatment. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2123. doi:10.1158/1538-7445.AM2015-2123
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.017 | 0.013 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".