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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Opus teacher head0.035
GPT teacher head0.295
- Teacher spread
- 0.260 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Nature Genetics
- Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Field
- Neuroscience
- Canadian institutions
- Occupational Cancer Research CentreUniversity of Toronto
- Funders
- National Center for Research ResourcesNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute on Deafness and Other Communication DisordersNational Eye InstituteNational Human Genome Research InstituteNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute on AgingNational Cancer InstituteEuropean Regional Development FundBijzonder Onderzoeksfonds UGentInstituto de Salud Carlos IIIMenzies Centre for Australian Studies, King's College London, University of LondonSixth Framework ProgrammeUniversity of California, IrvineUniversity of California, San FranciscoUniversity of California, San DiegoUniversity of California, DavisUniversity of California, Los AngelesGenentechNational Institutes of HealthVetenskapsrådetArizona Biomedical Research CommissionFundación Ramón ArecesUK Dementia Research InstituteInstituut Born-BungeIXICOHjartaverndBiogenMarcus och Amalia Wallenbergs minnesfondGeneralitat de CatalunyaUniversitat Autònoma de BarcelonaMinisterio de Economía y CompetitividadErasmus Medisch CentrumUniversity College London Hospitals NHS Foundation TrustMutuelle Générale de l'Education NationaleAcademy of FinlandServierSwedish Brain PowerNederlandse Organisatie voor Wetenschappelijk OnderzoekNorth Bristol NHS TrustUniversiteit AntwerpenUniversidad Autónoma de MadridKuopion Yliopistollinen SairaalaKarolinska InstitutetFonds Wetenschappelijk OnderzoekSouth London and Maudsley NHS Foundation TrustBelgian Federal Science Policy OfficeNational Center for Advancing Translational SciencesBundesministerium für Bildung und ForschungAXA Research FundMinistero della SaluteH. Lundbeck A/SInstitut National de la Santé et de la Recherche MédicaleDeutsche ForschungsgemeinschaftCardiff UniversityUniversity of NottinghamBrigham Young UniversityFondation pour la Recherche sur AlzheimerCanadian Institutes of Health ResearchEuropean CommissionBioClinicaNewcastle UniversityUniversitat de BarcelonaKing's College LondonOffice of Research and DevelopmentParkinson's UKVlaamse regeringNational Institute for Health and Care ResearchStichting MS ResearchUniversity of SouthamptonAlzheimer's SocietyCentro de Investigación Biomédica en Red sobre Enfermedades NeurodegenerativasAgence Nationale de la RechercheWellcome TrustArizona Department of Health ServicesJohns Hopkins UniversityDevelopment of Innovative Strategies for a Transdisciplinary approach to ALZheimer's diseaseCurePSPNorthern California Institute for Research and EducationUniversität des SaarlandesRush UniversityCentro de Biología Molecular Severo OchoaMotor Neurone Disease AssociationNovartis Pharmaceuticals CorporationZonMwUniversity of CambridgeStockholms Läns LandstingUniversity of PittsburghPfizerEU Joint Programme – Neurodegenerative Disease ResearchUniversity of WashingtonBrightFocus FoundationFondazione Cassa di Risparmio di Pistoia e PesciaAlzheimer's AssociationNorthwestern UniversityMedical Research CouncilMayo Foundation for Medical Education and ResearchEmory UniversityUniversidad de NavarraU.S. Department of Veterans AffairsFondation de FranceUniversity of PennsylvaniaSanofiEisaiUniversity of Southern CaliforniaU.S. Department of DefenseHersenstichtingEli Lilly and CompanyYork UniversityVanderbilt UniversityGlaxoSmithKlineMayo ClinicQueen's UniversityUniversity of MiamiMassachusetts General HospitalAgence Française de Sécurité Sanitaire des Produits de SantéMeso Scale DiagnosticsFondation pour la Recherche MédicaleBristol-Myers Squibb
- Keywords
- TREM2Nonsynonymous substitutionBiologyMinor allele frequencyGeneticsGenome-wide association studyMicrogliaAlzheimer's diseaseGenotypingAlleleGeneGenotypeAllele frequencyDiseaseSingle-nucleotide polymorphismImmunologyGenomeImmune systemMedicineInternal medicine
- Has abstract in OpenAlex
- no