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Record W2613009437 · doi:10.1111/anae.13891

Dexamethasone, blood glucose and <scp>CONSORT</scp> guidelines

2017· letter· en· W2613009437 on OpenAlexaffabout
R Lin, I. Ben Ahmed, Dylan Bould

Bibliographic record

VenueAnaesthesia · 2017
Typeletter
Languageen
FieldMedicine
TopicNausea and vomiting management
Canadian institutionsChildren's Hospital of Eastern Ontario
Fundersnot available
KeywordsMedicineDexamethasoneGlycemicPopulationVomitingNauseaConsolidated Standards of Reporting TrialsIncidence (geometry)Clinical trialRandomized controlled trialAnesthesiaInternal medicineInsulin

Abstract

fetched live from OpenAlex

We thank Tien et al. for their prospective randomised study on dexamethasone and blood glucose levels in diabetic and non-diabetic patients 1. We would like to invite the authors to address several questions that we have. We were surprised that the study did not follow CONSORT guidelines 2, which define the internationally accepted standard for reporting randomised controlled trials. Did the authors follow these guidelines and can they provide any insight into whether Anaesthesia insisted on a CONSORT statement during the publishing process? Key elements are missing; for instance, there was no mention of trial registration: can the investigators confirm that their outcome measures did not deviate from those determined a priori, as we could not find their trial registered on the website clinicaltrials.gov. It is also unclear where the study took place – are the researchers confident that their results are unaffected by population differences between Chile and the USA due to social determinants of health and pharmacokinetics? The dose of dexamethasone administered (8 mg) is higher than that normally used in the UK and Canada for postoperative anti-emesis. De Oliveira et al. concluded in their meta-analysis that there was no clinical advantage of 8 mg vs 4 mg dexamethasone on the incidence of postoperative nausea and/or vomiting 3. Do the authors think that postoperative blood glucose elevation might be avoided without affecting anti-emesis by simply not administering as much dexamethasone to patients?

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.258
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.053
GPT teacher head0.310
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2017
Admission routes2
Has abstractyes

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