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Association analyses based on false discovery rate implicate new loci for coronary artery disease

2017· article· en· 794 citations· W2735404270 on OpenAlex· 10.1038/ng.3913

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.025
GPT teacher head0.336
Teacher spread
0.311 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Genetics
Topic
Genetic Associations and Epidemiology
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Canadian Heart Research CentreUniversity of Ottawa
Funders
NIHR Sheffield Biomedical Research CentreEuropean Regional Development FundInterregPirkanmaan RahastoNational Institutes of HealthTaysNovo Nordisk FondenDiabetesliittoTampereen TuberkuloosisäätiöMedical Research CouncilSigne ja Ane Gyllenbergin SäätiöStockholms Läns LandstingKnut och Alice Wallenbergs StiftelseSuomen KulttuurirahastoKarolinska InstitutetNovo NordiskHjärt-LungfondenBritish Heart FoundationNational Institute for Health and Care ResearchImperial College Healthcare NHS TrustWellcome TrustCanadian Institutes of Health ResearchYrjö Jahnssonin SäätiöPfizerBiogenEuropean CommissionSanofiTorsten Söderbergs StiftelseVetenskapsrådetEmil Aaltosen SäätiöAstraZenecaEli Lilly and CompanySihtasutus ArchimedesImperial College LondonAndrea and Charles Bronfman Philanthropies
Keywords
Genome-wide association studyFalse discovery rateBiologyCoronary artery diseaseGenetic associationGeneticsBiobankMultiple comparisons problemBioinformaticsComputational biologySingle-nucleotide polymorphismInternal medicineMedicineGeneGenotype
Has abstract in OpenAlex
no