MétaCan
Menu
Back to cohort
Record W2735404270 · doi:10.1038/ng.3913

Association analyses based on false discovery rate implicate new loci for coronary artery disease

2017· article· en· W2735404270 on OpenAlexafffund
Christopher P. Nelson, Anuj Goel, Adam S. Butterworth, Stavroula Kanoni, Tom R. Webb, Eirini Marouli, Lingyao Zeng, Ιωάννα Ντάλλα, Florence Lai, Jemma C. Hopewell, Olga Giannakopoulou, Tao Jiang, Stephen E. Hamby, Emanuele Di Angelantonio, Themistocles L. Assimes, Erwin P. Böttinger, John C. Chambers, Robert Clarke, Richard M. Cubbon, Patrick T. Ellinor, Raili Ermel, Εvangelos Εvangelou, Paul W. Franks, Christopher Grace, Dongfeng Gu, Aroon D. Hingorani, Joanna M. M. Howson, Erik Ingelsson, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Terho Lehtimäki, Xiangfeng Lu, Yingchang Lu, Winfried März, Ruth McPherson, Andres Metspalu, Mar Pujades‐Rodríguez, Arno Ruusalepp, Eric E. Schadt, Amand F. Schmidt, Michael Sweeting, Pierre Zalloua, Kamal AlGhalayini, Bernard Keavney, Jaspal S. Kooner, Ruth J. F. Loos, Riyaz Patel, Martin K. Rutter, Maciej Tomaszewski, Ioanna Tzoulaki, Eleftheria Zeggini, Jeanette Erdmann, George Dedoussis, Johan Björkegren, Heribert Schunkert, Martin Farrall, John Danesh, Nilesh J. Samani, Hugh Watkins, Panos Deloukas

Bibliographic record

VenueNature Genetics · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsCanadian Heart Research CentreUniversity of Ottawa
FundersNIHR Sheffield Biomedical Research CentreEuropean Regional Development FundInterregPirkanmaan RahastoNational Institutes of HealthTaysNovo Nordisk FondenDiabetesliittoTampereen TuberkuloosisäätiöMedical Research CouncilSigne ja Ane Gyllenbergin SäätiöStockholms Läns LandstingKnut och Alice Wallenbergs StiftelseSuomen KulttuurirahastoKarolinska InstitutetNovo NordiskHjärt-LungfondenBritish Heart FoundationNational Institute for Health and Care ResearchImperial College Healthcare NHS TrustWellcome TrustCanadian Institutes of Health ResearchYrjö Jahnssonin SäätiöPfizerBiogenEuropean CommissionSanofiTorsten Söderbergs StiftelseVetenskapsrådetEmil Aaltosen SäätiöAstraZenecaEli Lilly and CompanySihtasutus ArchimedesImperial College LondonAndrea and Charles Bronfman Philanthropies
KeywordsGenome-wide association studyFalse discovery rateBiologyCoronary artery diseaseGenetic associationGeneticsBiobankMultiple comparisons problemBioinformaticsComputational biologySingle-nucleotide polymorphismInternal medicineMedicineGeneGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.116
metaresearch head score (Gemma)0.202
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.116
Threshold uncertainty score0.615

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1160.202
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.004
Bibliometrics0.0050.003
Science and technology studies0.0020.005
Scholarly communication0.0040.004
Open science0.0040.002
Research integrity0.0040.007
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.336
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations794
Published2017
Admission routes2
Has abstractno

Explore more

Same venueNature GeneticsSame topicGenetic Associations and EpidemiologyFrench-language works237,207