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Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.030
- Threshold uncertainty score
- 0.353
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Opus teacher head0.006
GPT teacher head0.234
- Teacher spread
- 0.228 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
The record
- Venue
- JAMA Psychiatry
- Topic
- Tryptophan and brain disorders
- Field
- Neuroscience
- Canadian institutions
- not available
- Funders
- Division of Cancer Epidemiology and Genetics, National Cancer InstituteNational Institute of Mental HealthNHLBI Division of Intramural ResearchInstitute of Molecular and Cell BiologyStanley Center for Psychiatric Research, Broad InstituteUniversity of North Carolina at Chapel HillSchool of Medicine, Emory UniversityNational Institutes of HealthMinistry of Cultural AffairsH. Lundbeck A/SMedical Research CouncilSiemens HealthineersTartu ÜlikoolLeids Universitair Medisch CentrumWestfälische Wilhelms-Universität MünsterDokuz Eylül ÜniversitesiVetenskapsrådetNovo NordiskUniversity of TorontoNederlands Instituut voor Onderzoek van de GezondheidszorgMedizinische Fakultät der Albert-Ludwigs-Universität FreiburgRegion HovedstadenGGZ DrentheInstitute of GeneticsDepartment of Psychiatry, University of TorontoUniversität GreifswaldGGZ FrieslandStatens Serum InstitutGGZ inGeestHáskóli ÍslandsBundesministerium für Bildung und ForschungJanssen Research and DevelopmentZonMwRijksuniversiteit GroningenNederlandse Organisatie voor Wetenschappelijk OnderzoekGentofte HospitalDeutsche ForschungsgemeinschaftAustralian Research CouncilTrinity College DublinUniversiteit LeidenSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungUniversity of GlasgowRheinische Friedrich-Wilhelms-Universität BonnUniversitair Medisch Centrum GroningenUniversità degli Studi di TrentoNewcastle UniversityVrije Universiteit AmsterdamStiftelsen för Strategisk ForskningUniversity of OxfordNational Cancer InstituteLundbeckfondenUniversity College LondonAlbert-Ludwigs-Universität FreiburgKing's College LondonAarhus UniversitetMassachusetts Institute of TechnologyUniversität BaselQIMR Berghofer Medical Research InstituteSouth London and Maudsley NHS Foundation TrustVirginia Commonwealth UniversityJames Cook UniversityCardiff UniversityUniversity of Texas Southwestern Medical CenterUniversity of Southern CaliforniaFoundation for the National Institutes of HealthBroad InstituteF. Hoffmann-La RocheQueensland University of TechnologyBrigham and Women's HospitalKaiser PermanenteQueensland Brain InstituteKarolinska InstitutetUniversity of QueenslandEmory UniversityNational Institute for Health and Care ResearchUniversidad de GranadaRigshospitaletAarhus UniversitetshospitalDalhousie UniversityUniversitätsmedizin GöttingenGlaxoSmithKlineCentre for Cognitive Ageing and Cognitive EpidemiologyWashington University in St. LouisEuropean CommissionWellcome TrustNational Science FoundationMassachusetts General HospitalRivierduinenPfizerMcDonnell Center for Systems NeuroscienceUniversity of California, San DiegoJohns Hopkins UniversityChinese Society of Clinical OncologyAmgen
- Keywords
- Depression (economics)Association (psychology)ObesityMedicineGenome-wide association studyPsychiatryPsychologyGeneticsBiologyInternal medicineSingle-nucleotide polymorphismGenotypeGenePsychotherapist
- Has abstract in OpenAlex
- yes