Novel genetic loci underlying human intracranial volume identified through genome-wide association

2016· article· en· W2768891580 on OpenAlexfundno aff

Hieab H.H. Adams, Derrek P. Hibar, Vincent Chouraki, Jason L. Stein, Paul Nyquist, Miguel E. Rentería, Stella Trompet, Alejandro Arias Vásquez, Sudha Seshadri, Sylvane Desrivières, Ashley Beecham, Neda Jahanshad, Katharina Wittfeld

Bibliographic record

VenueARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · 2016

Typearticle

Languageen

FieldNeuroscience

TopicNeurological Disease Mechanisms and Treatments

Canadian institutionsnot available

FundersCalifornia NanoSystems InstituteNational Center for Advancing Translational SciencesNational Institute of Neurological Disorders and StrokeNational Institute of Mental HealthNational Institute on AgingBiomedical Research CouncilInstituto de Salud Carlos IIINational Health and Medical Research CouncilAustralian Research CouncilNational Heart, Lung, and Blood InstituteBiotechnology and Biological Sciences Research CouncilCanadian Institutes of Health ResearchHeart And Stroke Foundation Of QuebecNational Institutes of HealthFundación Marqués de ValdecillaUniversität GreifswaldMedical Research CouncilEpilepsy SocietyUniversity College London Hospitals NHS Foundation TrustMutuelle Générale de l'Education NationaleRadboud Universitair Medisch CentrumGenome Institute of SingaporeUniversitair Medisch Centrum GroningenCentre d'Imagerie BioMédicaleLeids Universitair Medisch CentrumJapan Society for the Promotion of ScienceUniversitetet i BergenSanofiBroad InstituteFondation de FranceErasmus Medisch CentrumVrije Universiteit AmsterdamFondation pour la Recherche MédicaleUniversity of MinnesotaUniversiteit UtrechtNational Institutes of Natural SciencesZonMwUniversity of TorontoStichting voor de Technische WetenschappenCentre for Cognitive Ageing and Cognitive EpidemiologyUniversity of New South WalesNational Medical Research CouncilUniversiteit LeidenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalInstitut National de la Santé et de la Recherche MédicaleUniversity College LondonAccareAgency for Science, Technology and ResearchEuropean CommissionCentre hospitalier régional universitaire de LilleAge UKNational University Health SystemAlzheimer's AssociationScottish Funding CouncilHersenstichtingRadboud UniversiteitKoninklijke Nederlandse Akademie van WetenschappenMrs Gladys Row Fogo Charitable TrustWellcome TrustHjartaverndBergens ForskningsstiftelseJapan Agency for Medical Research and DevelopmentNederlandse Organisatie voor Wetenschappelijk OnderzoekBundesministerium für Bildung und ForschungMinistry of Education, Culture, Sports, Science and TechnologyHarvard UniversityCommonwealth Scientific and Industrial Research OrganisationNational Institute for Health and Care ResearchScience Foundation IrelandFondation LeducqNational Science FoundationTranslational Genomics Research InstituteMassachusetts General HospitalGlaxoSmithKlineU.S. Department of EnergyDevelopment of Innovative Strategies for a Transdisciplinary approach to ALZheimer's diseaseMax-Planck-GesellschaftAutism SpeaksBrain Research Imaging Centre, University of EdinburghBristol-Myers SquibbRoyal College of Surgeons in IrelandNorges ForskningsrådAustralian GovernmentHeart and Stroke Foundation of CanadaDirectorate for Biological SciencesUniversité de Lille

KeywordsGenome-wide association studyGenetic associationHuman genomeAssociation (psychology)BiologyVolume (thermodynamics)Brain sizeGenomeGeneticsComputational biologyEvolutionary biologyGeneMedicineSingle-nucleotide polymorphismGenotypePsychology

DOI10.13025/26699

Abstract

fetched live from OpenAlex

No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001

metaresearch head score (Gemma)0.000

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesMeta-epidemiology (narrow), Science and technology studies

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Bench or experimental · Consensus signal: none

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.921

Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.001	0.000
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.001	0.000
Bibliometrics	0.000	0.001
Science and technology studies	0.002	0.001
Scholarly communication	0.000	0.001
Open science	0.001	0.001
Research integrity	0.000	0.000
Insufficient payload (model declined to judge)	0.001	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.075

GPT teacher head0.275

Teacher spread0.200 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it