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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
Bibliographic record
VenueNature Genetics · 2017
Typearticle
Languageen
FieldMedicine
TopicDiet and metabolism studies
Canadian institutionsYork UniversityUniversité de MontréalDalhousie UniversityMontreal Heart Institute
FundersFP7 Ideas: European Research CouncilCarolina Population Center, University of North Carolina at Chapel HillNational Institute of Child Health and Human DevelopmentNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNational Center for Research ResourcesNational Institute of General Medical SciencesNational Human Genome Research InstituteNational Institute on Drug AbuseNational Institute on AgingNational Institute of Diabetes and Digestive and Kidney DiseasesNorwegian Institute of Public HealthDanish Agency for Science and Higher EducationNational Health and Medical Research CouncilNational Heart, Lung, and Blood InstituteBiotechnology and Biological Sciences Research CouncilCanadian Institutes of Health ResearchForsknings- og InnovationsstyrelsenDirectorate for Biological SciencesNational Institutes of HealthDiabetesforeningenMRC-PHE Centre for Environment and HealthCentre for Cognitive Ageing and Cognitive EpidemiologyH. Lundbeck A/SHjartaverndInstitut de Cardiologie de MontréalFondation Institut de Cardiologie de MontréalMedical Research CouncilServierRegione LombardiaBoehringer Ingelheim StiftungNational Center for Advancing Translational SciencesEconomic and Social Research CouncilUniversità degli Studi di VeronaFondation LeenaardsA.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene FormaalSydäntutkimussäätiöUniversitetet i BergenAarhus Universitets ForskningsfondMax-Planck-GesellschaftDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekMinistero della SaluteRegion HovedstadenEuropean Hematology AssociationNovo NordiskBritish Heart FoundationBundesministerium für Bildung und ForschungStrategiske ForskningsrådZonMwSystemsX.chSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungEuropean Foundation for the Study of DiabetesCancer Research UKNational University of SingaporeImperial College Healthcare NHS TrustWellcome TrustAarhus UniversitetAustralian GovernmentNorges ForskningsrådQIMR Berghofer Medical Research InstituteAstraZenecaNational Institute for Health Research Health Protection Research UnitEuropean CommissionSteno Diabetes Center CopenhagenNorges Teknisk-Naturvitenskapelige UniversitetWake Forest School of MedicineHelse VestJohns Hopkins UniversitySundhed og Sygdom, Det Frie ForskningsrådNational Cancer InstituteLundbeckfondenFoundation for Cardiovascular ResearchQueen Mary University of LondonNational Institute for Health and Care ResearchNational Science FoundationMassachusetts General HospitalIstituto Superiore di SanitàImperial College LondonEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentGlaxoSmithKlineErasmus Medisch CentrumAndrea and Charles Bronfman PhilanthropiesNovo Nordisk FondenAmerican Heart AssociationDiabetesforbundetPfizer
KeywordsBiologyBody mass indexObesityEnergy expenditureGeneticsEnergy metabolismEndocrinologyInternal medicine
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.029
Threshold uncertainty score0.708
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.014
GPT teacher head0.250
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations428
Published2017
Admission routes2
Has abstractyes