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Record W2789082224 · doi:10.1016/s2213-2600(18)30052-3

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

2018· review· en· W2789082224 on OpenAlexaff
Cheng‐Jian Xu, Cilla Söderhäll, Mariona Bustamante, Nour Baïz, Olena Gruzieva, Ulrike Gehring, Dan Mason, Leda Chatzi, Mikel Basterrechea, Sabrina Llop, Maties Torrent, Francesco Forastiere, Maria Pia Fantini, Karin C. Lødrup Carlsen, Tari Haahtela, Andréanne Morin, Marjan Kerkhof, Simon Kebede Merid, Bianca van Rijkom, Soesma A. Jankipersadsing, Marc Jan Bonder, Stéphane Ballereau, Cornelis J. Vermeulen, Raúl Aguirre‐Gamboa, Johan C. de Jongste, Henriëtte A. Smit, Ashish Kumar, Göran Pershagen, Stefano Guerra, Judith García‐Aymerich, Dario Greco, Lovisa E. Reinius, Rosemary McEachan, Raf Azad, Vegard Hovland, Petter Mowinckel, Harri Alenius, Nanna Fyhrquist, Nathanaël Lemonnier, Johann Pellet, Charles Auffray, Pieter van der Vlies, Cleo C. van Diemen, Yang Li, Cisca Wijmenga, Mihai G. Netea, Miriam F. Moffatt, William Cookson, Josep M. Antó, Jean Bousquet, Tiina Laatikainen, Catherine Laprise, Kai-Häkon Carlsen, Davide Gori, Daniela Porta, Carmen Íñiguez, José Ramón Bilbao, John Wright, Bert Brunekreef, Juha Kere, Martijn C. Nawijn, Isabella Annesi‐Maesano, Jordi Sunyer, Erik Melén, Gerard H. Koppelman

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2018
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEpigenetics and DNA Methylation
Canadian institutionsUniversité du Québec à ChicoutimiMcGill University and Génome Québec Innovation CentreCentre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-JeanMcGill Genome Centre
FundersGeneralitat de CatalunyaNederlandse Organisatie voor Wetenschappelijk OnderzoekCentres de Recerca de Catalunya
KeywordsDNA methylationCpG siteEpigenomeAsthmaMedicineMethylationEpigenomicsEpigeneticsDifferentially methylated regionsWhole bloodCord bloodImmunologyAllergyBioinformaticsGeneticsBiologyGeneGene expression

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.941
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.176
GPT teacher head0.397
Teacher spread0.221 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations252
Published2018
Admission routes1
Has abstractno

Explore more

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