Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Cell
- Topic
- Renal cell carcinoma treatment
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Stand Up To CancerNational Institutes of HealthCRUK Lung Cancer Centre of ExcellenceCancer Research UKNovo Nordisk FondenBreast Cancer Research FoundationRosetrees TrustNational Institute for Health and Care ResearchMinisterio de Economía y CompetitividadWellcome TrustFrancis Crick InstituteNational Cancer InstituteUniversity College LondonInstitute of Cancer ResearchMedical Research CouncilCelgeneRoyal Marsden Cancer Charity
- Keywords
- BiologyClear cell renal cell carcinomaMetastasisPhenotypeRenal cell carcinomaPrimary tumorCancer researchTumor progressionPathologyCancerGeneGenetics
- Has abstract in OpenAlex
- yes