ATIM-24. INTERIM RESULTS OF A PHASE II MULTICENTER STUDY OF THE CONDITIONALLY REPLICATIVE ONCOLYTIC ADENOVIRUS DNX-2401 WITH PEMBROLIZUMAB (KEYTRUDA) FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)
Bibliographic record
Abstract
DNX-2401 (tasadenoturev) is a replication-competent, tumor-selective, oncolytic adenovirus. A dose-escalating, Phase II study of a single intratumoral injection of DNX-2401 with pembrolizumab to determine optimal dose, safety and efficacy is ongoing and enrolling up to 48 patients with recurrent glioblastoma. Key inclusion criteria include patients with a single lesion at first or second recurrence for which resection is not possible or planned. In a dose-escalation design, a single intratumoral dose of DNX-2401 (5e8vp, 5e9vp, 5e10vp) is administered via cannula, followed 7 days later by 200 mg pembrolizumab Q3wk for up to 24 months or until confirmed progression, intolerable toxicity, or study withdrawal. Tumor response is assessed every 4 weeks for 6 months and every 8 weeks thereafter. As of 01May2018, 23 patients have been treated, with 17 at the optimal dose of 5e10vp DNX-2401. The median age and KPS at entry was 52 years (26–65) and 90 (80–100), respectively. The most frequent related grade 3–4 AEs across cohorts are headache (30%), fatigue (9%), and increased GGT (9%) consistent with disease or immune activation. Transient grade 1–3 lymphopenia has also been observed. Several cases of vasogenic edema have been managed with steroid tapers or low-dose bevacizumab. No patient has died or discontinued due to study treatment. The median treatment duration is 5.1 months for evaluable patients treated with DNX-2401 and pembrolizumab (N=15). Preliminary efficacy includes two partial responses and 100% 9-month survival for the first 7 patients treated. DNX-2401 followed by pembrolizumab is well tolerated, and data emerging for disease control and survival are encouraging. Updated results will be presented.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".