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Record W2900364017 · doi:10.1016/j.kint.2018.08.025

A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis

2018· article· en· W2900364017 on OpenAlex
Brad H. Rovin, Neil Solomons, William F. Pendergraft, Mary Anne Dooley, James A. Tumlin, Juanita Romero‐Díaz, Lidia V. Lysenko, Sandra Navarra, Robert B. Huizinga, Ihar Adzerikho, Е. И. Михайлова, Sergey Pimanov, Nikolay Soroka, Boris Bogov, Boriana Deliyska, Valentin Ikonomov, Eduard Tilkiyan, Ruth Almeida, Faud Teran, Irma Tchokhonelidze, N I Tsiskarishvili, Maynor Herrera Mendez, Nilmo Noel Chavez Perez, Arturo Reyes Loaeza, Sergio Ramon Gutierrez Urena, Juanita Romero Diaz, Rodolfo Araiza Casillas, Magdalena Madero Rovalo, Stanisław Niemczyk, Antoni Sokalski, Andrzej Więcek, Marian Klinger, О. В. Бугрова, Татьяна Михайловна Черных, Т. R. Kameneva, Т. А. Раскина, O. V. Reshetko, Н. Н. Везикова, Tatiana Kropotina, Adelya Maksudova, Vyacheslav Marasaev, Vladimir Dobronravov, И. Г. Гордеев, A. Essaian, А. В. Фролов, Rosa Jelačić, Dragan Jovanović, Branka Mitić, Gordana Peruničić Peković, Milan Radović, Goran Radunović, Patrícia Carreira, Federico Díaz‐González, Xavier Fulladosa, Eduardo Úcar, Shamila De Silva, Chula Herath, Anura Hewageegana, Abdul Nazar, Abdul Wazil, І. Dudar, Olga Godlevska, Svitlana Korneyeva, ViktoriIa Vasylets, N. Sydor, М. Kolesnyk, Samir V. Parikh, Nancy J. Olsen, Ellen M. Ginzler, Amit Saxena, Ramesh Saxena, Richard Lafayette, Amber S. Podoll, Annie Arrey‐Mensah, M Bubb, Jennifer M. Grossman, Alejandro I. Oporta, Alireza Nami, Md Mujibur Rahman, Syed Atiqul Haq, Tak Mao Chan, Mok Mo Yin Temy, Harold Michael P. Gomez, James Bermas, Bernadette Heizel M. Reyes, Llewellyn T. Hao, Linda Charmaine Roberto, Eric Amante, A Lanzon, Jung‐Yoon Choe, Tae Young Kang, Yon Su Kim, Seung‐Geun Lee, Ji Soo Lee, Jason Choo Chon Jun, Archana Vasudevan, Shue‐Fen Luo, Tien‐Tsai Cheng, Bancha Satirapoj, Kajohnsak Noppakun

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueKidney International · 2018
Typearticle
Languageen
FieldMedicine
TopicSystemic Lupus Erythematosus Research
Canadian institutionsAurinia (Canada)
Fundersnot available
KeywordsMedicinePlaceboLupus nephritisClinical endpointAdverse effectDose-ranging studyInternal medicineCalcineurinRandomized controlled trialGastroenterologyMulticenter trialUrologyTransplantationDouble blindMulticenter studyDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.362
Threshold uncertainty score0.394

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.306
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it