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Record W2900364017 · doi:10.1016/j.kint.2018.08.025

A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis

2018· article· en· W2900364017 on OpenAlexaff
Brad H. Rovin, Neil Solomons, William F. Pendergraft, Mary Anne Dooley, James A. Tumlin, Juanita Romero‐Díaz, Lidia V. Lysenko, Sandra Navarra, Robert B. Huizinga, Ihar Adzerikho, Е. И. Михайлова, Sergey Pimanov, Nikolay Soroka, Boris Bogov, Boriana Deliyska, Valentin Ikonomov, Eduard Tilkiyan, Ruth Almeida, Faud Teran, Irma Tchokhonelidze, N I Tsiskarishvili, Maynor Herrera Mendez, Nilmo Noel Chavez Perez, Arturo Reyes Loaeza, Sergio Ramon Gutierrez Urena, Juanita Romero Diaz, Rodolfo Araiza Casillas, Magdalena Madero Rovalo, Stanisław Niemczyk, Antoni Sokalski, Andrzej Więcek, Marian Klinger, О. В. Бугрова, Татьяна Михайловна Черных, Т. R. Kameneva, Т. А. Раскина, O. V. Reshetko, Н. Н. Везикова, Tatiana Kropotina, Adelya Maksudova, Vyacheslav Marasaev, Vladimir Dobronravov, И. Г. Гордеев, A. Essaian, А. В. Фролов, Rosa Jelačić, Dragan Jovanović, Branka Mitić, Gordana Peruničić Peković, Milan Radović, Goran Radunović, Patrícia Carreira, Federico Díaz‐González, Xavier Fulladosa, Eduardo Úcar, Shamila De Silva, Chula Herath, Anura Hewageegana, Abdul Nazar, Abdul Wazil, І. Dudar, Olga Godlevska, Svitlana Korneyeva, ViktoriIa Vasylets, N. Sydor, М. Kolesnyk, Samir V. Parikh, Nancy J. Olsen, Ellen M. Ginzler, Amit Saxena, Ramesh Saxena, Richard Lafayette, Amber S. Podoll, Annie Arrey‐Mensah, M Bubb, Jennifer M. Grossman, Alejandro I. Oporta, Alireza Nami, Md Mujibur Rahman, Syed Atiqul Haq, Tak Mao Chan, Mok Mo Yin Temy, Harold Michael P. Gomez, James Bermas, Bernadette Heizel M. Reyes, Llewellyn T. Hao, Linda Charmaine Roberto, Eric Amante, A Lanzon, Jung‐Yoon Choe, Tae Young Kang, Yon Su Kim, Seung‐Geun Lee, Ji Soo Lee, Jason Choo Chon Jun, Archana Vasudevan, Shue‐Fen Luo, Tien‐Tsai Cheng, Bancha Satirapoj, Kajohnsak Noppakun

Bibliographic record

VenueKidney International · 2018
Typearticle
Languageen
FieldMedicine
TopicSystemic Lupus Erythematosus Research
Canadian institutionsAurinia (Canada)
Fundersnot available
KeywordsMedicinePlaceboLupus nephritisClinical endpointAdverse effectDose-ranging studyInternal medicineCalcineurinRandomized controlled trialGastroenterologyMulticenter trialUrologyTransplantationDouble blindMulticenter studyDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0060.002
Bibliometrics0.0010.001
Science and technology studies0.0010.003
Scholarly communication0.0010.002
Open science0.0020.001
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.306
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations304
Published2018
Admission routes1
Has abstractno

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