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Record W2955556244 · doi:10.1038/s41565-019-0496-9

On the issue of transparency and reproducibility in nanomedicine

2019· letter· en· W2955556244 on OpenAlexaff
Hon S. Leong, Kimberly S. Butler, C. Jeffrey Brinker, May Azzawi, R. Steven Conlan, Christine Dufès, Andrew Owen, Steve P. Rannard, Chris Scott, Chunying Chen, Marina A. Dobrovolskaia, Serguei Kozlov, Adriele Prina‐Mello, Ruth Schmid, Peter Wick, Fanny Caputo, Patrick Boisseau, Rachael M. Crist, Scott E. McNeil, Bengt Fadeel, Lang Tran, Steffen Foss Hansen, Nanna B. Hartmann, Lauge Peter Westergaard Clausen, Lars Michael Skjolding, Anders Baun, Marlene Ågerstrand, Zhen Gu, Dimitrios A. Lamprou, Clare Hoskins, Leaf Huang, Wantong Song, Huiliang Cao, Xuanyong Liu, Klaus D. Jandt, Wen Jiang, Betty Y.S. Kim, Korin E. Wheeler, Andrew J. Chetwynd, Iseult Lynch, S. Moein Moghimi, André E. Nel, Tian Xia, Paul S. Weiss, Bruno Sarmento, José das Neves, Hélder A. Santos, Luis Santos, Samir Mitragotri, Steven R. Little, Dan Peer, Mansoor M. Amiji, Marı́a José Alonso, Alke Petri‐Fink, Sandor Balog, Aaron Lee, Barbara Drašler, Barbara Rothen‐Rutishauser, Stefan Wilhelm, Handan Acar, Roger G. Harrison, Chuanbin Mao, Priyabrata Mukherjee, Rajagopal Ramesh, Lacey R. McNally, Sara Busatto, Joy Wolfram, Paolo Bergese, Mauro Ferrari, Ronnie H. Fang, Liangfang Zhang, Jie Zheng, Chuanqi Peng, Bujie Du, Mengxiao Yu, Danielle M. Charron, Gang Zheng, Chiara Pastore

Bibliographic record

VenueNature Nanotechnology · 2019
Typeletter
Languageen
FieldMaterials Science
TopicNanoparticles: synthesis and applications
Canadian institutionsPrincess Margaret Cancer CentreUniversity of TorontoUniversity Health Network
FundersNational Institute of Biomedical Imaging and BioengineeringEngineering and Physical Sciences Research CouncilHorizon 2020 Framework ProgrammeNational Nuclear Security AdministrationNational Cancer InstituteNational Institutes of HealthCancer Research UKU.S. Department of Health and Human ServicesSandia National LaboratoriesU.S. Department of Energy
KeywordsTransparency (behavior)NanomedicineChecklistReproducibilityJoin (topology)NanotechnologyComputer scienceData scienceEngineering ethicsPolitical scienceMaterials sciencePsychologyComputer securityEngineeringChemistryMathematicsNanoparticleChromatography

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.057
metaresearch head score (Gemma)0.195
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Reproducibility · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.943
Threshold uncertainty score0.303

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0570.195
Meta-epidemiology (narrow)0.0010.002
Meta-epidemiology (broad)0.0020.004
Bibliometrics0.0020.002
Science and technology studies0.0140.019
Scholarly communication0.0160.019
Open science0.0070.008
Research integrity0.1700.146
Insufficient payload (model declined to judge)0.0080.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.250
Teacher spread0.239 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainReproducibility
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations226
Published2019
Admission routes1
Has abstractyes

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