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FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
MetaresearchScholarly communicationObservationalBench or experimental
Classifier consensus
ObservationalBench or experimental
Teacher imitation scores

Codex

Observational0.885
Scholarly communication0.362
Bench or experimental0.108
Not applicable0.052
Open science0.014
Metaresearch0.005
Other design0.003
Science and technology studies0.003
Systematic review0.001
Theoretical or conceptual0.001
Research integrity0.001
Qualitative0.000
Simulation or modelling0.000
Bibliometrics0.000
Randomized trial0.000
Meta-analysis0.000
Case report0.000
Non-randomized trial0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000

Gemma

Observational0.593
Metaresearch0.242
Bench or experimental0.085
Not applicable0.023
Research integrity0.018
Science and technology studies0.003
Open science0.002
Theoretical or conceptual0.002
Simulation or modelling0.002
Scholarly communication0.001
Qualitative0.001
Systematic review0.000
Non-randomized trial0.000
Randomized trial0.000
Meta-analysis0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Case report0.000
Meta-epidemiology (broad)0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.031
GPT teacher head0.353
Teacher spread
0.322 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic purposes and demonstrate its utility on the example of two use cases. We provide quality control metrics for the FDA-ARGOS genomic database resource and outline the need for genome quality gap filling in the public domain. In the first use case, we show…

Retrieved from PubMed through NCBI EFetch. Structured section labels are preserved.