Recent Advances Towards Syntheses of Diterpenoid Alkaloids
Why this work is in the frame
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Bibliographic record
Abstract
The diterpenoid alkaloids serve as a rich source of synthetic targets for organic chemists, due to the intriguing structure of the overlapping ring systems, along with biological activities commonly associated with compounds of this group. Fifteen total syntheses and numerous synthetic studies towards construction of ring fragments have been reported since 2010. This review article gives a brief overview of diterpenoid alkaloids and summarizes the recent synthetic efforts. 1 Introduction 1.1 Structural Classification and Biosynthetic Origin 1.2 Structure Elucidation of the Aconitum Alkaloids 2 Total Syntheses 2.1 C18-Diterpenoid Alkaloids 2.2 C19-Diterpenoid Alkaloids 2.3 C20-Diterpenoid Alkaloids 3 Strategies To Synthesize Ring Systems 3.1 Radical-Based Cyclizations 3.2 Ruthenium-Mediated Enyne Cycloisomerization 3.3 Reductive Coupling 3.4 Diels–Alder Reactions 3.5 Oxidative Dearomatization/Diels–Alder Sequence 3.6 Transannular Aziridation 3.7 Intramolecular [5+2] Cycloaddition 3.8 Miscellaneous 4 Conclusion
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.022 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it