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Record W2966901273 · doi:10.1074/jbc.ra119.009910

Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms

2019· article· en· W2966901273 on OpenAlexafffund
Natalie C. Bamford, François Le Mauff, Adithya S. Subramanian, Patrick Yip, Claudia Millán, Yongzhen Zhang, Caitlin Zacharias, Adam Forman, Mark Nitz, Jeroen D. C. Codée, Isabel Usón, Donald C. Sheppard, P. Lynne Howell

Bibliographic record

VenueJournal of Biological Chemistry · 2019
Typearticle
Languageen
FieldChemistry
TopicCarbohydrate Chemistry and Synthesis
Canadian institutionsMcGill UniversityMcGill University Health CentreInstitute of Infection and ImmunityHospital for Sick ChildrenSickKids FoundationUniversity of Toronto
FundersBiotechnology and Biological Sciences Research CouncilFonds de Recherche du Québec - SantéWestern Economic Diversification CanadaCanadian Institutes of Health ResearchNational Institutes of HealthUniversity of SaskatchewanHospital for Sick ChildrenNational Institute of General Medical SciencesMinisterio de Ciencia e InnovaciónUniversity of TorontoCystic Fibrosis CanadaMcGill UniversityMcGill University Health CentreBiological and Environmental ResearchGovernment of OntarioU.S. Department of EnergyNatural Sciences and Engineering Research Council of CanadaCanadian Light Source
KeywordsAspergillus fumigatusBiofilmMicrobiologyFungal pathogenPathogenAspergillusPathogenic organismBiologyChemistryBacteriaGenetics

Abstract

fetched live from OpenAlex

docking studies also uncovered the molecular determinants for galactosamine specificity and substrate binding at the -2 to +1 binding subsites. The findings in this study increase the structural and mechanistic understanding of the GH114 family, which has >600 members encoded by plant and opportunistic human pathogens, as well as in industrially used bacteria and fungi.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.025
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0150.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.232
Teacher spread0.200 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations58
Published2019
Admission routes2
Has abstractyes

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