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Occurrence and toxicity of a fusarium mycotoxin, zearalenone

2019· review· en· 381 citations· W2971157369 on OpenAlex· 10.1080/10408398.2019.1655388

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About CanadaIts subject is Canada, wherever its authors sit.

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Opus teacher head0.108
GPT teacher head0.347
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Abstract

Zearalenone (ZEA) is a mycotoxin produced by the fungi of Fusarium genera, which contaminates the cereals and food stuffs worldwide. Fusarium mycotoxins are considered as important metabolites related to animal and human health. Evidences indicate that ZEA has been found to be present in different food stuffs from developed countries like USA, Canada, France, Germany, Japan, etc. and developing nations like Egypt, Thailand, Iran, Croatia, Philippines, etc. The toxicokinetic studies reveal that following oral exposure of ZEA, the compound is absorbed through gastrointestinal tract (GIT), gets metabolized and distributed to different body parts. ZEA has been shown to cause reproductive disorders in laboratory animals. Although the toxicity of ZEA in humans have not been conclusively established nonetheless, limited evidences indicate that ZEA can cause hyper estrogenic syndrome. Though, ZEA causes low acute toxicity, but reports are available confirming the systemic toxicity caused by ZEA. There is no review available that addresses the occurrence, systemic toxicity and the probable mechanisms of ZEA toxicity. This review shall address the world-wide occurrence and in vivo & in vitro toxicity studies of ZEA over the past 20 years. The review shall also discuss the toxicokinetics of ZEA and metabolites; illustrates the systemic toxicity and probable mechanisms of action leading to the risk associated with ZEA.

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The record

Venue
Critical Reviews in Food Science and Nutrition
Topic
Mycotoxins in Agriculture and Food
Field
Agricultural and Biological Sciences
Canadian institutions
Funders
University Grants Commission
Keywords
ZearalenoneMycotoxinToxicityFusariumBiologyToxicokineticsZea maysTolerable daily intakeBiotechnologyToxicologyMedicineAgronomyBotanyBody weightInternal medicineEndocrinology
Has abstract in OpenAlex
yes