DNA methylation aging clocks: challenges and recommendations
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Abstract
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual.
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The record
- Venue
- Genome biology
- Topic
- Epigenetics and DNA Methylation
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Institute of GeneticsNational Institute of Environmental Health SciencesNational Institute of Allergy and Infectious DiseasesNational Institute of Mental HealthNational Institute for Health and Care ResearchNational Institute on AgingDepartment of Health and Social CareMedical Research CouncilNational Institutes of HealthRWTH Aachen UniversityEconomic and Social Research CouncilUniversity College London Hospitals NHS Foundation TrustNederlandse Organisatie voor Wetenschappelijk OnderzoekAlzheimer’s Research UKCancer Research UKBiotechnology and Biological Sciences Research CouncilZonMwJoint Programming Initiative A healthy diet for a healthy lifeDeutsche KrebshilfeNational Natural Science Foundation of ChinaNational Cancer InstituteUniversity of BristolDeutsche ForschungsgemeinschaftDiabetes UKBundesministerium für Bildung und ForschungNational Science FoundationUCLH Biomedical Research CentreAmerican Association for Cancer Research
- Keywords
- BiologyEpigenomicsDNA methylationEpigeneticsHuman geneticsEvolutionary biologyComputational biologyLongevityBiomarkerMolecular clockPopulationGeneticsCpG siteGeneGene expressionDemography
- Has abstract in OpenAlex
- yes