Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.004
- Threshold uncertainty score
- 0.235
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.280 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- The Lancet Neurology
- Topic
- Amyotrophic Lateral Sclerosis Research
- Field
- Medicine
- Canadian institutions
- Western UniversityUniversité LavalHôpital de l'Enfant-JésusUniversity of TorontoMcGill University Health CentreSunnybrook Health Science CentreHealth Sciences CentreUniversity of British Columbia
- Funders
- Janssen PharmaceuticalsNational Institute of Neurological Disorders and StrokeNational Institute on AgingUCLH Biomedical Research CentreNational Health and Medical Research CouncilMedical Research CouncilGE HealthcareAlzheimer's Disease Research Center, Emory UniversityGenentechCentre Hospitalier Universitaire de NîmesInstitut de FranceHjärnfondenDemensfondenH. Lundbeck A/SStockholm läns landstingCentre Hospitalier Universitaire de NiceFédération pour la Recherche sur le CerveauRocheStockholms Läns LandstingBiogenAgence Nationale de la RechercheBundesministerium für Bildung und ForschungGuarantors of BrainNational Institute for Health and Care ResearchAssociation France ParkinsonStichting DioraphteWellcome TrustOntario Ministry of Economic Development and InnovationPfizerEU Joint Programme – Neurodegenerative Disease ResearchAstex PharmaceuticalsWeston Brain InstituteAlzheimerfondenKarolinska InstitutetZonMwNational Institutes of HealthAlzheimer's Drug Discovery FoundationTauRx PharmaceuticalsUCBMinistero della SaluteAssistance Publique - Hôpitaux de ParisAbbVieFondation Brain CanadaVetenskapsrådetCytokineticsNational Medical Research CouncilAlzheimer NederlandInstituto de Salud Carlos IIIUK Dementia Research InstituteOntario Brain InstituteMinistero dello Sviluppo EconomicoHeart and Stroke Foundation of CanadaNederlandse Organisatie voor Wetenschappelijk OnderzoekNovartisFondation Roger de SpoelberchEli Lilly and CompanyAmgenAssociation for Frontotemporal DegenerationAlexion PharmaceuticalsCanadian Institutes of Health ResearchAlzheimer's Society
- Keywords
- C9orf72Frontotemporal dementiaAge of onsetDementiaRetrospective cohort studyMedicineDiseaseCohortInternal medicineOncologyPediatrics
- Has abstract in OpenAlex
- no