Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
VenueGastroenterology · 2019
Typearticle
Languageen
FieldMedicine
TopicGrowth Hormone and Insulin-like Growth Factors
Canadian institutionsMemorial University of NewfoundlandLunenfeld-Tanenbaum Research InstituteUniversity of TorontoMount Sinai Hospital
FundersDivision of Cancer Epidemiology and Genetics, National Cancer InstituteNational Center for Advancing Translational SciencesNational Institute of Environmental Health SciencesNational Institute on AgingMedicinska fakulteten, Umeå UniversitetEuropean Regional Development FundInstituto de Salud Carlos IIINational Health and Medical Research CouncilNational Institute of Diabetes and Digestive and Kidney DiseasesWorld Cancer Research FundMedical Research CouncilCanadian Institutes of Health ResearchU.S. Public Health ServiceCenters for Disease Control and PreventionChonnam National University Hwasun HospitalHellenic Health FoundationJunta de Castilla y LeónWereld Kanker Onderzoek FondsXunta de GaliciaBundesministerium für Bildung und FrauenDeutsche KrebshilfeAssociazione Italiana per la Ricerca sul CancroNordForskVetenskapsrådetOntario Institute for Cancer ResearchBundesministerium für Bildung und ForschungMinisterio de Economía y CompetitividadCancerfondenNational Cancer InstituteFundación Científica Asociación Española Contra el CáncerInstitut National de la Santé et de la Recherche MédicaleConseil Régional des Pays de la LoireEuropean Cooperation in Science and TechnologyMinisterstvo Zdravotnictví Ceské RepublikyCentre Hospitalier Universitaire de NantesEuropean CommissionGeneralitat de CatalunyaFood Standards AgencyChonnam National UniversityCentres de Recerca de CatalunyaInstitut Gustave-RoussyGrantová Agentura České RepublikyU.S. Department of Health and Human ServicesMayo ClinicJohns Hopkins UniversityCentre International de Recherche sur le CancerCancer Research Foundation in Northern SwedenLigue Contre le CancerDeutsches KrebsforschungszentrumUniversity of PittsburghStockholms Läns LandstingCancer Council VictoriaKræftens BekæmpelseMemorial Sloan-Kettering Cancer CenterNational Research CouncilAssociation Anne de Bretagne GenetiqueSwedish Cancer FoundationUniversity of South FloridaÖsterreichische ForschungsförderungsgesellschaftNational Institutes of HealthMike and Josie Harper Cancer Research InstituteNational Heart, Lung, and Blood InstituteFlorida Department of HealthWageningen University and ResearchCancer Research UKXarxa de Bancs de Tumors de CatalunyaWorld Health OrganizationUniversity of CambridgeAmerican Cancer SocietyVicHealthMutuelle Générale de l'Education NationaleMinisterie van Volksgezondheid, Welzijn en SportAmerican Institute for Cancer ResearchDamon Runyon Cancer Research FoundationMoffitt Cancer CenterAgència de Gestió d'Ajuts Universitaris i de RecercaNational Institute for Health and Care ResearchDivision of Cancer Prevention, National Cancer Institute
KeywordsMendelian randomizationIGFBP3Colorectal cancerMedicineHazard ratioOncologyInternal medicineOdds ratioCancerInsulin-like growth factorRisk factorProportional hazards modelConfidence intervalGenotypeBiologyGrowth factorGeneticsGenetic variants
Abstract
fetched live from OpenAlexBACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development. METHODS: ). Colorectal cancer risk was associated with only 1 variant in the IGFBP3 gene region (rs11977526), which also associated with anthropometric traits and circulating level of IGF2. CONCLUSIONS: In an analysis of blood samples from almost 400,000 participants in the UK Biobank, we found an association between circulating level of IGF1 and colorectal cancer. Using genetic data from 52,865 cases with colorectal cancer and 46,287 controls, a higher level of IGF1, determined by genetic factors, was associated with colorectal cancer. Further studies are needed to determine how this signaling pathway might contribute to colorectal carcinogenesis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.103
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
