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Record W3005328263 · doi:10.1016/j.neuron.2020.01.008

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

2020· article· en· W3005328263 on OpenAlexafffund
Lin Luo, Mateusz C. Ambrozkiewicz, Fritz Benseler, Cui Chen, Émilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei‐Hsiang Huang, Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi, Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira, Thomas Philips, Jennifer L. Sinclair, Jeffrey A. Stogsdill, Lisa Traunmüller, Jie‐Xin Wang, Joke Wortel, Wenjia You, Nashat Abumaria, Kevin T. Beier, Nils Brose, Harold A. Burgess, Constance L. Cepko, Jean-François Cloutier, Çağla Eroğlu, Sandra Goebbels, Pascal S. Kaeser, Jeremy N. Kay, Wei Lü, Liqun Luo, Kenji Mandai, Chris J. McBain, Klaus‐Armin Nave, Marco A. M. Prado, Vânia F. Prado, Jeffrey Rothstein, John L.R. Rubenstein, Gesine Saher, Kenji Sakimura, Joshua R. Sanes, Peter Scheiffele, Yoshimi Takai, Hisashi Umemori, Matthijs Verhage, Michisuke Yuzaki, Huda Y. Zoghbi, Hiroshi Kawabe, Ann Marie Craig

Bibliographic record

VenueNeuron · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPlant Reproductive Biology
Canadian institutionsWestern UniversityMcGill University Health CentreMontreal Neurological Institute and HospitalMcGill UniversityUniversity of British Columbia
FundersNational Institute of Child Health and Human DevelopmentNational Institute of Neurological Disorders and StrokeNational Institute on Drug AbuseJapan Society for the Promotion of ScienceFudan UniversityEuropean Research CouncilNatural Sciences and Engineering Research Council of CanadaMax-Planck-GesellschaftEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentChinese Academy of SciencesJapan Science and Technology AgencyHoward Hughes Medical InstituteNational Natural Science Foundation of ChinaDeutsche ForschungsgemeinschaftEuropean CommissionSimons Foundation Autism Research InitiativeNational Eye InstituteMinistry of Education, Culture, Sports, Science and TechnologyNational Institute of Mental HealthScience and Technology Commission of Shanghai MunicipalityNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Science FoundationEuropean Molecular Biology OrganizationCanadian Institutes of Health Research
KeywordsGermlineRecombinaseBiologyGeneticsCre recombinaseRecombinationLocus (genetics)GeneHomologous recombinationTransgene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.207
Teacher spread0.194 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations196
Published2020
Admission routes2
Has abstractno

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