Cells of the adult human heart
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- Teacher spread
- 0.217 · how far apart the two teachers sit on this one work
- Validation status
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Abstract
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
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The record
- Venue
- Nature
- Topic
- Single-cell and spatial transcriptomics
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of Alberta
- Funders
- National Institutes of HealthAlberta InnovatesChina Scholarship CouncilBundesministerium für Bildung und ForschungDeutsches Zentrum für Herz-KreislaufforschungEuropean CommissionUniversity of AlbertaDeutsche ForschungsgemeinschaftSarnoff Cardiovascular Research FoundationBritish Heart FoundationHoward Hughes Medical InstituteChan Zuckerberg InitiativeAlexander von Humboldt-StiftungWellcome TrustNational Heart, Lung, and Blood InstituteHeart and Stroke Foundation of CanadaCanadian Institutes of Health ResearchNational Science Foundation
- Keywords
- TranscriptomeBiologyCell typeMyocyteImmune systemCellNeuroscienceHuman heartCardiac muscleCell biologyCardiac VentricleHeart diseaseGene expressionMedicinePathologyAnatomyGeneImmunologyInternal medicineGenetics
- Has abstract in OpenAlex
- yes