Computational and biological studies of novel thiazolyl coumarin derivatives synthesized through Suzuki coupling
Bibliographic record
Abstract
Antibiotic resistance is one of the leading public health concerns of the current age The plausible causes of the antimicrobial resistance are the widespread use of antibiotics and the weary antibiotic research progress Similarly, the incidence of systemic fungal infection has become an important complication and a major cause of morbidity and mortality in immune compromised individuals, such as those who are receiving anticancer chemotherapy, those who have had organ transplants, and AIDS patients In many antimicrobial drugs, the heterocyclic thiazole nucleus are an integral part of the drug as pharmacophore Drug designing techniques have led to the designing of novel coumarin scaffold with various bioactive entities in order to realize pharmacophores with good pharmacology as well as enhanced pharmacokinetics A large number of studies have been conducted on the combined effect of thiazole and coumarin scaffolds that show improved biological activities The present study is based on in vitro antibacterial and antifungal screening of small drug-like thiazole coumarin derivatives.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".