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Record W3121184362 · doi:10.1038/s41588-020-00762-2

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

2021· review· en· W3121184362 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueNature Genetics · 2021
Typereview
Languageen
FieldMedicine
TopicCardiomyopathy and Myosin Studies
Canadian institutionsWestern UniversityUniversité de MontréalMontreal Heart Institute
FundersNational Cancer InstituteNIH Office of the DirectorNational Institute on Drug AbuseNIHR Oxford Biomedical Research CentreEngineering and Physical Sciences Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchAmsterdam Cardiovascular Sciences, Amsterdam University Medical CentersNational Institute of Mental HealthHorizon 2020 Framework ProgrammeMason Medical Research TrustKlaus Tschira StiftungWellcome TrustImperial College Healthcare NHS TrustBHF Centre of Research Excellence, OxfordStichting Volksbond RotterdamFédération Française de CardiologieUniversità degli Studi di FirenzeZonMwCommon FundNetherlands Heart InstituteJapan Society for the Promotion of ScienceDeutsches Zentrum für Herz-KreislaufforschungHeart Rhythm SocietyImperial College LondonFondation Institut de Cardiologie de MontréalUK Research and InnovationNational Institute for Health and Care ResearchAgence Nationale de la RechercheFondation LeducqNational Human Genome Research InstituteUK Dementia Research InstituteAmsterdam University Medical CentersNational Institutes of HealthEuropean Research Area Network on Cardiovascular DiseasesRosetrees TrustEuropean CommissionEuropean Society of CardiologyNational Heart, Lung, and Blood InstituteAcademy of Medical SciencesNational Institute of Neurological Disorders and StrokeBritish Heart FoundationInstitut de Cardiologie de MontréalHeart and Stroke Foundation of Canada
KeywordsHypertrophic cardiomyopathyDilated cardiomyopathyGenome-wide association studyMendelian randomizationInternal medicineBiologyCardiologyHeart failureBiobankGeneticsGenotypeGenetic variantsGeneMedicineSingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.948
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.277
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it