MétaCan
Menu
Back to cohort
Record W3121184362 · doi:10.1038/s41588-020-00762-2

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect

2021· review· en· W3121184362 on OpenAlexafffund
Rafik Tadros, Catherine Francis, Xiao Yun Xu, Alexa M.C. Vermeer, Andrew R. Harper, Roy Huurman, Ken Kelu Bisabu, Roddy Walsh, Edgar T. Hoorntje, Wouter P. te Rijdt, Rachel Buchan, Hannah G. van Velzen, Marjon A. van Slegtenhorst, Jentien M. Vermeulen, Joost A. Offerhaus, Wenjia Bai, Antonio de Marvao, Najim Lahrouchi, Leander Beekman, Jacco C. Karper, Jan H. Veldink, Elham Kayvanpour, Antonis Pantazis, A. John Baksi, Nicola Whiffin, Francesco Mazzarotto, Geraldine Sloane, Hideaki Suzuki, Deborah Schneider-Luftman, Paul Elliott, Pascale Richard, Flavie Ader, Eric Villard, Peter Lichtner, Thomas Meitinger, Michael W.T. Tanck, J. Peter van Tintelen, Andrew Thain, David McCarty, Robert A. Hegele, Jason D. Roberts, Julie Amyot, Marie‐Pierre Dubé, Julia Cadrin‐Tourigny, Geneviève Giraldeau, Philippe L. L’Allier, Patrick Garceau, Jean‐Claude Tardif, S. Matthijs Boekholdt, R Thomas Lumbers, Folkert W. Asselbergs, Paul J.R. Barton, Stuart A. Cook, Sanjay Prasad, Declan P. O’Regan, Jolanda van der Velden, Karin J. H. Verweij, Mario Talajic, Guillaume Lettre, Yigal M. Pinto, Benjamin Meder, Philippe Charron, Rudolf A. de Boer, Imke Christiaans, Michelle Michels, Arthur A.M. Wilde, Hugh Watkins, Paul M. Matthews, James S. Ware, Connie R. Bezzina

Bibliographic record

VenueNature Genetics · 2021
Typereview
Languageen
FieldMedicine
TopicCardiomyopathy and Myosin Studies
Canadian institutionsWestern UniversityUniversité de MontréalMontreal Heart Institute
FundersNational Cancer InstituteNIH Office of the DirectorNational Institute on Drug AbuseNIHR Oxford Biomedical Research CentreEngineering and Physical Sciences Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchAmsterdam Cardiovascular Sciences, Amsterdam University Medical CentersNational Institute of Mental HealthHorizon 2020 Framework ProgrammeMason Medical Research TrustKlaus Tschira StiftungWellcome TrustImperial College Healthcare NHS TrustBHF Centre of Research Excellence, OxfordStichting Volksbond RotterdamFédération Française de CardiologieUniversità degli Studi di FirenzeZonMwCommon FundNetherlands Heart InstituteJapan Society for the Promotion of ScienceDeutsches Zentrum für Herz-KreislaufforschungHeart Rhythm SocietyImperial College LondonFondation Institut de Cardiologie de MontréalUK Research and InnovationNational Institute for Health and Care ResearchAgence Nationale de la RechercheFondation LeducqNational Human Genome Research InstituteUK Dementia Research InstituteAmsterdam University Medical CentersNational Institutes of HealthEuropean Research Area Network on Cardiovascular DiseasesRosetrees TrustEuropean CommissionEuropean Society of CardiologyNational Heart, Lung, and Blood InstituteAcademy of Medical SciencesNational Institute of Neurological Disorders and StrokeBritish Heart FoundationInstitut de Cardiologie de MontréalHeart and Stroke Foundation of Canada
KeywordsHypertrophic cardiomyopathyDilated cardiomyopathyGenome-wide association studyMendelian randomizationInternal medicineBiologyCardiologyHeart failureBiobankGeneticsGenotypeGenetic variantsGeneMedicineSingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.277
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations292
Published2021
Admission routes2
Has abstractno

Explore more

Same venueNature GeneticsSame topicCardiomyopathy and Myosin StudiesFrench-language works237,207