Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
VenueAging · 2021
Typearticle
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsnot available
FundersJanssen Alzheimer Immunotherapy Research And DevelopmentJohnson and Johnson Pharmaceutical Research and DevelopmentNational Human Genome Research InstituteNational Heart, Lung, and Blood InstituteNational Institute on AgingUniversitätsklinikum Hamburg-EppendorfEuropean Regional Development FundInstituto de Salud Carlos IIIMenzies Centre for Australian Studies, King's College London, University of LondonCambridge Institute for Medical Research, University of CambridgeNational Institutes of HealthNational Institute of Neurological Disorders and StrokeArizona Biomedical Research CommissionNational Institute of Diabetes and Digestive and Kidney DiseasesIXICODevelopment of Innovative Strategies for a Transdisciplinary approach to ALZheimer's diseaseCentro de Investigación Biomédica en Red sobre Enfermedades NeurodegenerativasUniversité Pierre et Marie CurieUniversity of BristolH. Lundbeck A/SMeso Scale DiagnosticsAgence Française de Sécurité Sanitaire des Produits de SantéSanofiFondation de FranceFonds Wetenschappelijk OnderzoekFondation pour la Recherche MédicaleBelgian Federal Science Policy OfficeUniversity College LondonAlbert-Ludwigs-Universität FreiburgInstitut National de la Santé et de la Recherche MédicaleMedical Research CouncilServierUniversität HeidelbergGenentechFondation pour la Recherche sur AlzheimerEuropean CommissionEU Joint Programme – Neurodegenerative Disease ResearchPfizerInstituto de Investigación Marqués de ValdecillaVlaamse regeringUniversity of OxfordEisaiUniversity of Southern CaliforniaWellcome TrustEli Lilly and CompanyBrigham Young UniversityCanadian Institutes of Health ResearchUniversity of SouthamptonUniversiteit AntwerpenNorthern California Institute for Research and EducationInstitute of GeneticsAgence Nationale de la RechercheBiogenBioClinicaAlzheimer's AssociationEuropean Federation of Pharmaceutical Industries and AssociationsArizona Department of Health ServicesF. Hoffmann-La RocheEmory UniversityCardiff UniversityU.S. Department of DefenseMutuelle Générale de l'Education NationaleBristol-Myers SquibbNational Center for Advancing Translational SciencesNovartis Pharmaceuticals CorporationAlzheimer's Disease Neuroimaging InitiativeRheinische Friedrich-Wilhelms-Universität Bonn
KeywordsApolipoprotein EDiseaseConcordanceAlleleGenome-wide association studyDementiaAlzheimer's diseaseBiologyOmicsComputational biologyBiomarkerBioinformaticsMedicineGeneticsGeneSingle-nucleotide polymorphismInternal medicineGenotype
Abstract
fetched live from OpenAlexAD cases that could constitute screening tools for a disease that lacks specific blood biomarkers. Beside the identification of APOE-specific signatures, our findings advocate that this novel approach, based on the concordance across OMIC layers and tissues, is an effective strategy for overcoming the limitations of often underpowered single-OMICS studies.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.218
Threshold uncertainty score0.998
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
